First off, Remove Spybot. It makes too many false positives. Find the
application's .exe file you are trying to run and right click
on it. If you see "Block this" at the bottom of the properties box
then unblock it. As for Spybot Michelle, there are other great
free programs lile SpywareBlaster and SpywareGuard that will help you
keep the Crap out. Let me know if this helps please.