Viral glycoproteins are not always randomly distributed
By Vincent Racaniello on Aug 16, 2018 09:43 pm The membranes of enveloped viruses contain embedded proteins that are essential for attaching to cell receptors and fusing with cell membranes. We generally view these glycoproteins as evenly distributed over the surface of the virus particle, as illustrated for influenza virus. But many more envelope glycoproteins are involved in attachment and entry of larger viruses, […]
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Trial By Error: The BPS Brigades Score Another Own Goal
By David Tuller on Aug 15, 2018 07:49 pm By David Tuller, DrPH Not long ago, Sir Simon scored an own goal by enticing a childhood buddy to enter the PACE debate. That buddy, attorney and social commentator Mike Godwin, soon pronounced the trial—which Sir Simon had called “a thing of beauty”–to be “so profoundly flawed that it cannot be trusted.” Sir Simon tweeted […]
Read in browser » Trial By Error: Open Letter to The Lancet, version 3.0
By David Tuller on Aug 13, 2018 12:22 am By David Tuller, DrPH Two months ago, Professor Racaniello sent Lancet editor Richard Horton an open letter about the indisputable methodological and ethical failings of the PACE trial. This was a follow-up to Virology Blog’s 2016 open letter to Dr. Horton; the new one detailed what has happened since then. Last month, I re-sent and […]
Read in browser » TWiV 506: A Cafeteria full of jelly rolls
By Vincent Racaniello on Aug 12, 2018 10:58 am The TWiVniks explain how the three-dimensional structure of the giant Cafeteria roenbergensis virus suggests a new mode of assembly, and the apparent elimination of dengue fever in an Australian city by release of mosquitoes harboring Wolbachia. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” […]
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