PNAS this week from Biology

[Saumyadip Sarkar]

Biological Sciences

Applied Biological Sciences

Ionic liquids for oral insulin delivery

Amrita Banerjee, Kelly Ibsen, Tyler Brown, Renwei Chen, Christian Agatemor, and Samir Mitragotri

Biochemistry

Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease

Elena S. Klimtchuk, Tatiana Prokaeva, Nicholas M. Frame, Hassan A. Abdullahi, Brian Spencer, Surendra Dasari, Haili Cui, John L. Berk, Paul J. Kurtin, Lawreen H. Connors, and Olga Gursky

Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils 

Francesco Simone Ruggeri, Fabrizio Benedetti, Tuomas P. J. Knowles, Hilal A. Lashuel, Sergey Sekatskii, and Giovanni Dietler

O-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2

Pei-Wen Lo, Jiun-Jie Shie, Chein-Hung Chen, Chung-Yi Wu, Tsui-Ling Hsu, and Chi-Huey Wong

Catalytic iron-carbene intermediate revealed in a cytochrome c carbene transferase

Russell D. Lewis, Marc Garcia-Borràs, Matthew J. Chalkley, Andrew R. Buller, K. N. Houk, S. B. Jennifer Kan, and Frances H. Arnold

The mutagen and carcinogen cadmium is a high-affinity inhibitor of the zinc-dependent MutLα endonuclease 

Shanen M. Sherrer, Elisabeth Penland, and Paul Modrich

Structure of the Lassa virus glycan shield provides a model for immunological resistance 

Yasunori Watanabe, Jayna Raghwani, Joel D. Allen, Gemma E. Seabright, Sai Li, Felipe Moser, Juha T. Huiskonen, Thomas Strecker, Thomas A. Bowden, and Max Crispin

Ionophoric effects of the antitubercular drug bedaquiline

Kiel Hards, Duncan G. G. McMillan, Lici A. Schurig-Briccio, Robert B. Gennis, Holger Lill, Dirk Bald, and Gregory M. Cook

Capsid protein structure, self-assembly, and processing reveal morphogenesis of the marine virophage mavirus 

Diana Born, Lukas Reuter, Ulrike Mersdorf, Melanie Mueller, Matthias G. Fischer, Anton Meinhart, and Jochen Reinstein

Biophysics and Computational Biology

Gene expression distribution deconvolution in single-cell RNA sequencing 

Jingshu Wang, Mo Huang, Eduardo Torre, Hannah Dueck, Sydney Shaffer, John Murray, Arjun Raj, Mingyao Li, and Nancy R. Zhang

Reversible inhibition of the ClpP protease via an N-terminal conformational switch

Siavash Vahidi, Zev A. Ripstein, Massimiliano Bonomi, Tairan Yuwen, Mark F. Mabanglo, Jordan B. Juravsky, Kamran Rizzolo, Algirdas Velyvis, Walid A. Houry, Michele Vendruscolo, John L. Rubinstein, and Lewis E. Kay

Structural basis for recognition of human 7SK long noncoding RNA by the La-related protein Larp7

Catherine D. Eichhorn, Yuan Yang, Lucas Repeta, and Juli Feigon

Molecular model of human tropoelastin and implications of associated mutations

Anna Tarakanova, Giselle C. Yeo, Clair Baldock, Anthony S. Weiss, and Markus J. Buehler

Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly

Xurong Wang, Fuxian Zhang, Rui Su, Xiaowu Li, Wenyuan Chen, Qingxiu Chen, Tao Yang, Jiawei Wang, Hongrong Liu, Qin Fang, and Lingpeng Cheng

Cell Biology

Targeting β1-integrin inhibits vascular leakage in endotoxemia 

Laura Hakanpaa, Elina A. Kiss, Guillaume Jacquemet, Ilkka Miinalainen, Martina Lerche, Camilo Guzmán, Eero Mervaala, Lauri Eklund, Johanna Ivaska, and Pipsa Saharinen

PIP30/FAM192A is a novel regulator of the nuclear proteasome activator PA28γ 

Beata Jonik-Nowak, Thomas Menneteau, Didier Fesquet, Véronique Baldin, Catherine Bonne-Andrea, Francisca Méchali, Bertrand Fabre, Prisca Boisguerin, Sylvain de Rossi, Corinne Henriquet, Martine Pugnière, Manuelle Ducoux-Petit, Odile Burlet-Schiltz, Angus I. Lamond, Philippe Fort, Séverine Boulon, Marie-Pierre Bousquet, and Olivier Coux

F-actin homeostasis through transcriptional regulation and proteasome-mediated proteolysis

Masayuki Onishi, Kresti Pecani, Taylor Jones IV, John R. Pringle, and Frederick R. Cross

Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane 

Alex Burdyga, Nicoletta C. Surdo, Stefania Monterisi, Giulietta Di Benedetto, Francesca Grisan, Elisa Penna, Luca Pellegrini, Mario Bortolozzi, Pawel Swietach, Tullio Pozzan, and Konstantinos Lefkimmiatis

Resistance to Plasmodium falciparum in sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition

Natasha M. Archer, Nicole Petersen, Martha A. Clark, Caroline O. Buckee, Lauren M. Childs, and Manoj T. Duraisingh

ZNF281 inhibits neuronal differentiation and is a prognostic marker for neuroblastoma 

Marco Pieraccioli, Sara Nicolai, Consuelo Pitolli, Massimiliano Agostini, Alexey Antonov, Michal Malewicz, Richard A. Knight, Giuseppe Raschellà, and Gerry Melino

Ecology

Whole-genome data reveal the complex history of a diverse ecological community 

Lynsey Bunnefeld, Jack Hearn, Graham N. Stone, and Konrad Lohse

Fisheries bycatch risk to marine megafauna is intensified in Lagrangian coherent structures 

Kylie L. Scales, Elliott L. Hazen, Michael G. Jacox, Frederic Castruccio, Sara M. Maxwell, Rebecca L. Lewison, and Steven J. Bograd

Large-scale replicated field study of maize rhizosphere identifies heritable microbes 

William A. Walters, Zhao Jin, Nicholas Youngblut, Jason G. Wallace, Jessica Sutter, Wei Zhang, Antonio González-Peña, Jason Peiffer, Omry Koren, Qiaojuan Shi, Rob Knight, Tijana Glavina del Rio, Susannah G. Tringe, Edward S. Buckler, Jeffery L. Dangl, and Ruth E. Ley

Disease outbreak thresholds emerge from interactions between movement behavior, landscape structure, and epidemiology

Lauren A. White, James D. Forester, and Meggan E. Craft

Evolution

Changes in brain architecture are consistent with altered fear processing in domestic rabbits 

Irene Brusini, Miguel Carneiro, Chunliang Wang, Carl-Johan Rubin, Henrik Ring, Sandra Afonso, José A. Blanco-Aguiar, Nuno Ferrand, Nima Rafati, Rafael Villafuerte, Örjan Smedby, Peter Damberg, Finn Hallböök, Mats Fredrikson, and Leif Andersson

Mutational and transcriptional landscape of spontaneous gene duplications and deletions in Caenorhabditis elegans

Anke Konrad, Stephane Flibotte, Jon Taylor, Robert H. Waterston, Donald G. Moerman, Ulfar Bergthorsson, and Vaishali Katju

Genetics

Real-time dynamics of mutagenesis reveal the chronology of DNA repair and damage tolerance responses in single cells

Stephan Uphoff

Evolutionary genomic dynamics of Peruvians before, during, and after the Inca Empire 

Daniel N. Harris, Wei Song, Amol C. Shetty, Kelly S. Levano, Omar Cáceres, Carlos Padilla, Víctor Borda, David Tarazona, Omar Trujillo, Cesar Sanchez, Michael D. Kessler, Marco Galarza, Silvia Capristano, Harrison Montejo, Pedro O. Flores-Villanueva, Eduardo Tarazona-Santos, Timothy D. O’Connor, and Heinner Guio

Gentamicin induces LAMB3 nonsense mutation readthrough and restores functional laminin 332 in junctional epidermolysis bullosa

Vadim Lincoln, Jon Cogan, Yingping Hou, Michaela Hirsch, Michelle Hao, Vitali Alexeev, Michele De Luca, Laura De Rosa, Johann W. Bauer, David T. Woodley, and Mei Chen

miR-34a directly targets tRNA_i^Met precursors and affects cellular proliferation, cell cycle, and apoptosis 

Bo Wang, Dongping Li, Igor Kovalchuk, Ingrid J. Apel, Arul M. Chinnaiyan, Rafał K. Wóycicki, Charles R. Cantor, and Olga Kovalchuk

Sex-chromosome dosage effects on gene expression in humans

Armin Raznahan, Neelroop N. Parikshak, Vijay Chandran, Jonathan D. Blumenthal, Liv S. Clasen, Aaron F. Alexander-Bloch, Andrew R. Zinn, Danny Wangsa, Jasen Wise, Declan G. M. Murphy, Patrick F. Bolton, Thomas Ried, Judith Ross, Jay N. Giedd, and Daniel H. Geschwind

Immunology and Inflammation

Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth

Ilenia Pacella, Claudio Procaccini, Chiara Focaccetti, Stefano Miacci, Eleonora Timperi, Deriggio Faicchia, Martina Severa, Fabiana Rizzo, Eliana Marina Coccia, Fabrizia Bonacina, Nico Mitro, Giuseppe Danilo Norata, Grazisa Rossetti, Valeria Ranzani, Massimiliano Pagani, Ezio Giorda, Yu Wei, Giuseppe Matarese, Vincenzo Barnaba, and Silvia Piconese

Targeting the IL33–NLRP3 axis improves therapy for experimental cerebral malaria

Patrick Strangward, Michael J. Haley, Manuel G. Albornoz, Jack Barrington, Tovah Shaw, Rebecca Dookie, Leo Zeef, Syed M. Baker, Emma Winter, Te-Chen Tzeng, Douglas T. Golenbock, Sheena M. Cruickshank, Stuart M. Allan, Alister Craig, Foo Y. Liew, David Brough, and Kevin N. Couper

Medical Sciences

Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation

M. C. Gage, N. Bécares, R. Louie, K. E. Waddington, Y. Zhang, T. H. Tittanegro, S. Rodríguez-Lorenzo, A. Jathanna, B. Pourcet, O. M. Pello, J. V. De la Rosa, A. Castrillo, and I. Pineda-Torra

Drosophila model of myosin myopathy rescued by overexpression of a TRIM-protein family member

Martin Dahl-Halvarsson, Montse Olive, Malgorzata Pokrzywa, Katarina Ejeskär, Ruth H. Palmer, Anne Elisabeth Uv, and Homa Tajsharghi

Autoantibodies reactive to adrenocorticotropic hormone can alter cortisol secretion in both aggressive and nonaggressive humans 

Henning Værøy, Csaba Adori, Romain Legrand, Nicolas Lucas, Jonathan Breton, Caroline Cottard, Jean-Claude do Rego, Céline Duparc, Estelle Louiset, Hervé Lefebvre, Pierre Déchelotte, Elin Western, Stein Andersson, Tomas Hökfelt, and Sergueï O. Fetissov

Microbiology

Coupled laboratory and field investigations resolve microbial interactions that underpin persistence in hydraulically fractured shales 

Mikayla A. Borton, David W. Hoyt, Simon Roux, Rebecca A. Daly, Susan A. Welch, Carrie D. Nicora, Samuel Purvine, Elizabeth K. Eder, Andrea J. Hanson, Julie M. Sheets, David M. Morgan, Richard A. Wolfe, Shikha Sharma, Timothy R. Carr, David R. Cole, Paula J. Mouser, Mary S. Lipton, Michael J. Wilkins, and Kelly C. Wrighton

Direct cell–cell contact activates SigM to express the ESX-4 secretion system in Mycobacterium smegmatis

Ryan R. Clark, Julius Judd, Erica Lasek-Nesselquist, Sarah A. Montgomery, Jennifer G. Hoffmann, Keith M. Derbyshire, and Todd A. Gray

Arthropod EVs mediate dengue virus transmission through interaction with a tetraspanin domain containing glycoprotein Tsp29Fb

Ashish Vora, Wenshuo Zhou, Berlin Londono-Renteria, Michael Woodson, Michael B. Sherman, Tonya M. Colpitts, Girish Neelakanta, and Hameeda Sultana

Inhibitor of intramembrane protease RseP blocks the σ^E response causing lethal accumulation of unfolded outer membrane proteins

Anna Konovalova, Marcin Grabowicz, Carl J. Balibar, Juliana C. Malinverni, Ronald E. Painter, Daniel Riley, Paul A. Mann, Hao Wang, Charles G. Garlisi, Brad Sherborne, Nathan W. Rigel, Dante P. Ricci, Todd A. Black, Terry Roemer, Thomas J. Silhavy, and Scott S. Walker

In vivo imaging of the pathophysiological changes and neutrophil dynamics in influenza virus-infected mouse lungs

Hiroshi Ueki, I-Hsuan Wang, Satoshi Fukuyama, Hiroaki Katsura, Tiago Jose da Silva Lopes, Gabriele Neumann, and Yoshihiro Kawaoka

Enhancement of Ebola virus infection by seminal amyloid fibrils

Stephen M. Bart, Courtney Cohen, John M. Dye, James Shorter, and Paul Bates

Staphylococcus aureus biofilms release leukocidins to elicit extracellular trap formation and evade neutrophil-mediated killing

Mohini Bhattacharya, Evelien T. M. Berends, Rita Chan, Elizabeth Schwab, Sashwati Roy, Chandan K. Sen, Victor J. Torres, and Daniel J. Wozniak

Interplay of a secreted protein with type IVb pilus for efficient enterotoxigenic Escherichia coli colonization 

Hiroya Oki, Kazuki Kawahara, Takahiro Maruno, Tomoya Imai, Yuki Muroga, Shunsuke Fukakusa, Takaki Iwashita, Yuji Kobayashi, Shigeaki Matsuda, Toshio Kodama, Tetsuya Iida, Takuya Yoshida, Tadayasu Ohkubo, and Shota Nakamura

Neuroscience

Piano training enhances the neural processing of pitch and improves speech perception in Mandarin-speaking children

Yun Nan, Li Liu, Eveline Geiser, Hua Shu, Chen Chen Gong, Qi Dong, John D. E. Gabrieli, and Robert Desimone

Focal, remote-controlled, chronic chemical modulation of brain microstructures

Khalil B. Ramadi, Canan Dagdeviren, Kevin C. Spencer, Pauline Joe, Max Cotler, Erin Rousseau, Carlos Nunez-Lopez, Ann M. Graybiel, Robert Langer, and Michael J. Cima

Tandem internal models execute motor learning in the cerebellum 

Takeru Honda, Soichi Nagao, Yuji Hashimoto, Kinya Ishikawa, Takanori Yokota, Hidehiro Mizusawa, and Masao Ito

Action potential counting at giant mossy fiber terminals gates information transfer in the hippocampus 

Simon Chamberland, Yulia Timofeeva, Alesya Evstratova, Kirill Volynski, and Katalin Tóth

Physiology

Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH

Hari Prasad and Rajini Rao

Plant Biology

Multigenome analysis implicates miniature inverted-repeat transposable elements (MITEs) in metabolic diversification in eudicots 

Alexander M. Boutanaev and Anne E. Osbourn

Degradation of unmethylated miRNA/miRNA*s by a DEDDy-type 3′ to 5′ exoribonuclease Atrimmer 2 in Arabidopsis

Xiaoyan Wang, Yuan Wang, Yongchao Dou, Lu Chen, Junli Wang, Ning Jiang, Chunce Guo, Qingqing Yao, Chizao Wang, Lin Liu, Bin Yu, Binglian Zheng, Julia A. Chekanova, Jinbiao Ma, and Guodong Ren

Psychological and Cognitive Sciences

Dissecting the neurofunctional bases of intentional action

Laura Zapparoli, Silvia Seghezzi, Paola Scifo, Alberto Zerbi, Giuseppe Banfi, Marco Tettamanti, and Eraldo Paulesu

--

Mr. Saumyadip Sarkar

TIGP MCB Graduate Student (PhD),

Academia Sinica, Taipei, Taiwan

Blog: Biomysteries

@iamsaumyadip

Linkedin Profile

+886-909560976