The only thing you need to think about is to make sure you shut down the Raspberry Pi when you want to reboot the NAS. I still leave those three weewx directories as NFS mounts (on the same NAS).
Once BerryBoot has been configured with the iSCSI Target and an OS installed, it can be flagged as the default OS so it boots up automatically, no manual intervention required. It displays the boot menu for 20 secs (default time) before booting the default OS. If you run headless (no monitor attached), it can be configured to run up a VNC server so you can view the boot menu and configure remotely. Once the OS starts booting, you do lose the VNC.
The other advantage is that you end up with a fast filesystem - faster than the SD card. It will also work over WiFi but I have not tried it. I expect it wouldn't be as stable (or as fast) as using an Ethernet cable. Also, because it uses the NAS filesystem, you can also utilise the NAS's snapshot and backup features - depends on how paranoid you want to be.
It's not a solution for everyone but it impressed me so I kept using it.
Peter