I'm building a game engine which allows combining OpenStreetMap roads with ESRI terrain data to convert any location on Earth into a multiplayer game. I also sent this email to Khronos where you pointed.
This is a very good timing as I'm getting closer to finishing an MVP of a game engine which takes any location in the world and creates drivable roads. Complex intersections are still buggy when imported but they can be manually adjusted in the editor after importing.
The game engine is built on top of Three.js with multiple parts of the renderer rewritten and features added to the core as vanilla Three.js is not that great for really big scenes. This engine has auto instancing, auto impostors, static shadow caching, using sampler2DShadow for shadows instead of Three's custom materials, workerised collision detection and many other performance upgrades which allow showing large scale scenes.
Here's a quick 2min demo of the entire process. From importing the terrain and the roads, launching the game server to some gameplay.