I just tried running the todo-backend-fsharp app on a Mac in Xamarin Studio. Things apparently work quite differently. I don't really understand all the issues but have found several issues related to locating the F# targets that appear to be happening to me. I resolved those in a not-so-nice way, and now I'm getting an even stranger exception trying to launch the web app.
We clearly have a lot of work in this area. So much for, "it should just work." Dave, do you have any time to look at this with me?
Cheers,
Ryan