HI Isimmo! I hope you are well!
Yes, you can do it. Check this Example:
I created one folder called test that contains 3 folders called testdir1, testdir2, and testdir3.
And in the configuration file:
<syscheck>
<disabled>no</disabled>
<directories>c:\test\*</directories>
</syscheck>
so, if you can note in the logs, with this way all the folders inside the test will be monitored by FIM
So, in your case maybe you can try to use C:\Users\*(username)\Desktop
I hope this helps you!
Regards, Camila!