Hi,
We would need more information to help you troubleshoot it.
Let's first check the active response logs on the Agent side
C:\Program Files (x86)\ossec-agent\active-response\active-response.log. If the file is empty, it could be a configuration issue.
Make sure, you placed the enable_defender.exe is located exactly here on the Agent:
C:\Program Files (x86)\ossec-agent\active-response\bin\.
Additionally, change the location to local:
<active-response>
<disabled>no</disabled>
<command>enable_defender</command>
<location>local</location>
<rules_id>62152</rules_id>
</active-response>
Bear in mind if you are in a cluster environment, all the nodes must have the same Active Reponse configuration. Restart the server, force the rule and share with us the active-response.log of the agent.