Plex Extensions

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Lajuana Paling

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Aug 3, 2024, 3:25:08 PM8/3/24

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Cerebral protein profiling in traumatic brain injury (TBI) is needed to better comprehend secondary injury pathways. Cerebral microdialysis (CMD), in combination with the proximity extension assay (PEA) technique, has great potential in this field. By using PEA, we have previously screened >500 proteins from CMD samples collected from TBI patients. In this study, we customized a PEA panel prototype of 21 selected candidate protein biomarkers, involved in inflammation (13), neuroplasticity/-repair (six), and axonal injury (two). The aim was to study their temporal dynamics and relation to age, structural injury, and clinical outcome. Ten patients with severe TBI and CMD monitoring, who were treated in the Neurointensive Care Unit, Uppsala University Hospital, Sweden, were included. Hourly CMD samples were collected for up to 7 days after trauma and analyzed with the 21-plex PEA panel. Seventeen of the 21 proteins from the CMD sample analyses showed significantly different mean levels between days. Early peaks (within 48 h) were noted with interleukin (IL)-1β, IL-6, IL-8, granulocyte colony-stimulating factor, transforming growth factor alpha, brevican, junctional adhesion molecule B, and neurocan. C-X-C motif chemokine ligand 10 peaked after 3 days. Late peaks (>5 days) were noted with interleukin-1 receptor antagonist (IL-1ra), monocyte chemoattractant protein (MCP)-2, MCP-3, urokinase-type plasminogen activator, Dickkopf-related protein 1, and DRAXIN. IL-8, neurofilament heavy chain, and TAU were biphasic. Age (above/below 22 years) interacted with the temporal dynamics of IL-6, IL-1ra, vascular endothelial growth factor, MCP-3, and TAU. There was no association between radiological injury (Marshall grade) or clinical outcome (Extended Glasgow Outcome Scale) with the protein expression pattern. The PEA method is a highly sensitive molecular tool for protein profiling from cerebral tissue in TBI. The novel TBI dedicated 21-plex panel showed marked regulation of proteins belonging to the inflammation, plasticity/repair, and axonal injury families. The method may enable important insights into complex injury processes on a molecular level that may be of value in future efforts to tailor pharmacological TBI trials to better address specific disease processes and optimize timing of treatments.

I started my journey training with the best, at The Academy of Scientific Hair Design. I come from a legacy of hair stylists, taught in the legendary haute couture practices of France. For the next 8 years I apprenticed under my mother, Nelly Gauthe, a renowned French stylist. It was there that I developed skills and clientele to work for myself. For the last 17 1/2 years, I've had successful business.

Thanks to what I've learned through intensive training and hard work, (put together with what I believe to be my natural born talent and gift) I've opened SolaPlex Salon, right in Old Metairie inside Sola Salon Studios.

My clients get the look and style they want with an added benefit of maintaining the style at home. A few hair tricks and some product knowledge will help you feel comfortable with maintenance!

Offering hair services to women, men, and children, I do custom coloring, hi-lights, relaxers, perms, and Keratin for all hair types, while keeping the integrity of the hair my main priority and offering Olaplex treatments. I always welcome new clients!
Come on in and get great service while having a great time and share some laughs. I give my best to each and every client and I guarantee you will leave looking and feeling great! So, invest in your hair- it's the crown you never take off!

** We must not forget that the salon is not child proof. Sharp implements, hot styling tools, chemicals and a congested area make for a potentially dangerous environment for young children. While this policy helps ensure that all guests enjoy a relaxing salon experience, it was created with your child's safety in mind. We kindly request only those receiving service be present in the service areas.

I recently installed CIVIL 3D 2023. when i try to run PVX_RIBBON_FIX in order to load Plex Earth, CAD does not recognize the command, therefore i cannot run PE in CAD 2023. Both the ribbon command and PE run in CIVIL 3D 2021, so the software seems to be correct. i have uninstalled and reinstalled plex earth and no change. i have uninstalled 2023 Civil 3D and no change. Has anyone had this issue and know of a potential fix?

Everything I've seen has pointed toward needing to install Plex Earth 2023, reading on Plex Earth's website, it only lists 2022 as the max version compatible with 5D. Its a little surprising that their tech support has not pointed that out.

Currently the plex-desktop snap is unable to work on Wayland without passing DISABLE_WAYLAND=1 via the environment. @tamas are you involved in the desktop snap at all, or are you server only? If you can would it be possible to either change the environment block to the following in the snapcraft.yaml for plex-desktop or convince someone who can to do so?

from the picture of the licensing it looks ok but that would only be important for synology's own software like videostation or moments, plex just uses the hardware device and its own codecs (i guess, i dont use transcoding and will not spend money just for being able to test with plex)

that combination wouldn't even boot 918+, your picture shows a 6400 (looks like you forgot to mention you tinkered with other stuff already, you used the patch for shown the real cpu), that cpu is a 6th gen (skylake)

I am a big fan of Plex Media Server-- it has a great set of software, both server and client side, and is much easier to setup and use than alternatives such as XBMC. Attached to my ReadyNAS, my Plex server has access to 6 TB of storage.

I also have several Chromecast devices-- they're great little media streamer sticks that simply plug into your HDMI port on your TV. Using your phone as a remote, you can "cast" media from an app (such as Netflix, HBO, or Plex) and onto your TV. Chromecast also has a browser API, so Plex's website also allows you to cast media to your local TVs.

There's one major issue, however, in terms of compatibility between Plex and the Chromecast-- and it's not actually the Chromecast's fault. Plex, for whatever reason, has decided to limit the maximum bitrate of a video file to 12 mbps when casting to a Chromecast device. If you have a powerful PC running as your Plex server, this is fine-- the server software will transcode the higher bitrate videos on the fly to 12 mbps. But, I am using an old laptop that can barely transcode to 4 mbps, 720p video files, so the video playback stutters.

Plex claims this forced transcoding is due to "performance issues" with media over 12 mbps, but this is not true1. Not only have users casted media higher than 12 mbps from other apps, but I have successfully gotten around this hard coded limitation and streamed 20+ mbps video without a problem.

Note: This is a detailed post on how I figured out my workaround, and contains some technical material on advanced Javascript concepts. If you are an end user that just wants to perform the fix yourself, please see my separate how-to guide:

First, the media is checked against an XML based profile for your device that is located on your Plex server. This profile contains info about what device supports what features, and if the media is too high resolution or too high bitrate, Plex decides to transcode the video to a compatible format. The Chromecast file specifies a maximum bitrate of 12,000 kbps.

But, what if we change this XML profile to specify a maximum bitrate of 30,000 kbps? This would solve the problem for most devices, but this does not fix the issue for the Chromecast. Some people believe that they are fixing the issue by changing the XML, but this is not true. There is in fact a second place where this 12,000 kbps limitation is enforced, and it is not changeable by conventional means.

Chromecast apps are composed of two things-- a sender application, which can be a native mobile app or a web application for Chrome, and a receiver application that runs on the Chromecast. The Chromecast also has several types of receiver applications, including the default video player (which basically allows you to send a URL to it and it will use a default UI for playback) and a custom receiver. The custom receiver is essentially a web page and can run most code any web browser can, allowing you to style and program the application to do more than just play a simple video.

Plex has opted to use a custom receiver in order to display poster art on your screen, among other things. However, since custom applications can run arbitrary code, they have hard coded a 12,000 kbps limitation for videos, which overrides the XML profile on your server.

Don't believe me? Check for yourself-- the Plex Chromecast app is composed of several files: an HTML page, which serves as the view you see on your screen, and a Javascript file with logic for communicating with Plex2. These files are located at:

In the plex.js file, search for the line containing maxBitrate: 12000. If you're a programmer, you can follow the code, but essentially this maximum bitrate overrides any other maximum bitrate sent to the Chromecast (such as the one that is sent to the Chromecast from the XML profile).

You have to look for something a little bit different: "maxBitrate":12e3. In case you're curious why this is, it is because the compressor (really, it is called a "minifier") converts the number 12,000 into the shorter "12e3", which is simply exponential notation for the same value. This allows the file to be smaller, and reduce network overhead and the time to download the Javascript application to your Chromecast. Many websites use this technique, and because the Chromecast is web based, Chromecast applications should do this as well.