The Rose Blanche harbour was first used by French migratory fishermen who came in the early 1700s to fish the nearby Rose Blanche Bank which had an abundance of cod. The harbor provided good anchorage, being well sheltered by Caines Island and Rose Blanche Point. The name Rose Blanche is a corruption of the French words "roche blanche" (white rock) which can be seen at Diamond Cove. This white quartz was highly visible to the French migratory fishermen when they first approached the shore in the early 1700s.
The first settlers in Rose Blanche arrived and probably settled in 1810, though the French had held seasonal premises in the area in the 18th century. Rose Blanche was first settled for its sheltered harbours and close location to fishing grounds.
By the 1869 census, the population had grown to 663, and the area continued to attract new settlers from England and the Channel Islands to participate in the fishery. By the 1870s the community had a number of businesses which participated in the local fishery and the Labrador fishery.
The 1950s and 1960s brought significant changes to the community with the opening of a fresh-frozen fish plant, plus resettlement of outlying communities in Rose Blanche, as a result of the road connection completed between Rose Blanche and Port aux Basques in 1961. St. Michael's Elementary school was shut down by the government due to lack of funding. There is also a small gas station, a couple of restaurants, and a new artists' retreat centre and guest house called "RoseSea House".
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