World War 2 War In The Pacific

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Suk Harian

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Aug 4, 2024, 8:22:40 PM8/4/24
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Nomatter where business or pleasure takes you, oneworld's vast network means your Round The World trip via oneworld Explorer fare makes it easy to travel from city to city, and continent to continent. And, for every dot you connect, you earn more miles and points to spend across the oneworld Alliance.

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Pacific University presents "Risky Business: Sports Mega-Events, Tourism, and The Road to Conviviality", a lecture by NYU Professor Christopher Gaffney, who works with municipalities, hospitality enterprises, and civil society on long-term planning and integrated systems design.


One Young World is the global community for young leaders. It inspires young leaders to increase their social impact, builds their skills and capacity, and elevates their profiles both locally and globally.


Delegates return to their communities and organisations as One Young World Ambassadors with the connections, insights, and motivation to act, accessing the global community of 15,500+ young leaders to accelerate existing social impact initiatives or establish new ventures.


One Young World strives to identify the most impactful young leaders from every country in the world. Scholarships provide the opportunity for exceptional young people to attend on the merit of their proven leadership and ability to create change in their home country. Leading The Pacific is an initiative designed to ensure that outstanding young people from the Pacific are represented at One Young World Summits.


Young leaders across the Pacific are devising meaningful strategies to build a more sustainable region. Are you one of those leaders? If so, One Young World is looking to bring you to our next annual Summit.


Please note that if you are ultimately selected for a Scholarship and require a visa to enter Canada to attend the One Young World Summit 2024, you will be required to pay the visa fee yourself. The visa costs 165 Canadian Dollars plus the applicable service charge of your local visa application centre. The costs of the visa and the applicable service charge as well as any further costs associated with the visa application (including travel to and from the visa application centre) fall on you as the participant.


*Most delegates are between the age of 18 and 30. The One Young World team will consider applications from those who are older than 30, pending demonstration of appropriate personal impact, initiative, and willingness to engage. We are not able to accept applications from those who will be aged under 18 at the time of the Summit.


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Median real-world progression-free survival was 24.6 months in the durvalumab arm and 9.6 months in the control arm. Median time to next treatment was 28.6 months and 11.7 months, respectively. No new safety signals were identified in association with the regimen. The most common adverse event of special interest was pneumonitis/interstitial lung disease, with an incidence of 20% (all grades).


At a median follow-up of 23 months, 56% of the patients had disease progression, 34% had died, and 20% had discontinued durvalumab because of adverse events. The median progression-free survival was 22.3 months, and median overall survival was 43.7 months. Age, performance status, PD-L1 expression, and early discontinuation or timing of durvalumab commencement were not significantly associated with any difference in these outcomes. The first site of relapse was intrathoracic for 45%, extrathoracic for 32%, and intracranial for 23% of patients.


PACIFIC-R is an international, observational study conducted as a retrospective review of established medical records of patients with unresectable, stage III NSCLC treated with durvalumab after chemoradiotherapy within an AstraZeneca-initiated early access program between September 2017 and December 2018. The primary endpoints were investigator-assessed real-world progression-free survival and overall survival. Outcome according to EGFR status was exploratory.


In addition, the time to first subsequent therapy was shorter among patients with EGFR mutations (median = 16.7 vs 43.1 months). Approximately 45% of patients with EGFR mutations developed distant metastases, and 75% of them received an EGFR-targeted tyrosine kinase inhibitor as their first subsequent therapy, she added.


3. Pringle N, Flether JA, Morton C, et al: Real world experience of survival outcomes in consolidative durvalumab in unresectable stage III non-small cell lung cancer. 2023 World Conference on Lung Cancer. Abstract EP08.02-03. Presented September 7, 2023.


4. Girard N, Bar J, Garrido P, et al: Treatment characteristics and real-world progression-free survival in patients with unresectable stage III NSCLC who received durvalumab after chemoradiotherapy: Findings from the PACIFIC-R study. J Thorac Oncol 18:181-193, 2023.


8. Lee C, Liao BC, Subramaniam S, et al: ILLUMINATE: Efficacy and safety of durvalumab-tremelimumab and chemotherapy in EGFR mutant NSCLC following progression on EGFR inhibitors. 2023 World Lung Cancer Conference. Abstract OA09.04. Presented September 11, 2021.


Holding more than half of the Earth's open water supply, the Pacific Ocean was named by explorer Ferdinand Magellan in 1520, who called this body of water "pacific," due to the calmness of the water at the time ('pacific' means peaceful).

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