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Imaging has become a valuable tool in the assessment of neuromuscular diseases, and, specifically, quantitative MR imaging provides robust biomarkers for the monitoring of disease progression. Quantitative evaluation of fat infiltration and quantification of the T2 values of the muscular tissue's water component (wT2) are two of the most essential indicators currently used. As each voxel of the image can contain both water and fat, a two-component model for the estimation of wT2 must be used. In this work, we present a fast method for reconstructing wT2 maps obtained from conventional multi-echo spin-echo (MESE) acquisitions and released as Free Open Source Software. The proposed software is capable of fast reconstruction thanks to extended phase graphs (EPG) simulations and dictionary matching implemented on a general-purpose graphic processing unit. The program can also perform more conventional biexponential least-squares fitting of the data and incorporate information from an external water-fat acquisition to increase the accuracy of the results. The method was applied to the scans of four healthy volunteers and five subjects suffering from facioscapulohumeral muscular dystrophy (FSHD). Conventional multi-slice MESE acquisitions were performed with 17 echoes, and additionally, a 6-echo multi-echo gradient-echo (MEGE) sequence was used for an independent fat fraction calculation. The proposed reconstruction software was applied on the full datasets, and additionally to reduced number of echoes, respectively, to 8, 5, and 3, using EPG and biexponential least-squares fitting, with and without incorporating information from the MEGE acquisition. The incorporation of external fat fraction maps increased the robustness of the fitting with a reduced number of echoes per datasets, whereas with unconstrained fitting, the total of 17 echoes was necessary to retain an independence of wT2 from the level of fat infiltration. In conclusion, the proposed software can successfully be used to calculate wT2 maps from conventional MESE acquisition, allowing the usage of an optimized protocol with similar precision and accuracy as a 17-echo acquisition. As it is freely released to the community, it can be used as a reference for more extensive cohort studies.
If the application is aware of TCP Fast Open, the application can ask for TCP Fast Open behavior using the TCP_FASTOPEN option in setsockopt(). When that is set, as can be seen in the implementation of do_tcp_setsockopt, the key is generated by calling tcp_fastopen_init_key_once() from some random bytes.
You can use the sysctl tunable net.ipv4.tcp_fastopen_key to set a system-wide TFO key to be used by processes that are not aware of TFO. Here is a discussion in Wikimedia's tech wiki of TFO - which I assume is for managing Wikimedia's servers TFO support - at the end of it they have sample code to update the system TFO key.
Internet service providers have always delivered open, unrestricted internet service. Consumers everyday enjoy the web content and applications of their choosing. Broadband providers continue to deliver consumers an internet with more competitive choices, faster speeds, and lower prices than ever before.
But not everything is well documented in the blogpost! first of you need to have 1607 build to get suppor for TCP fast open in the Windows Kernel. If you have TCP fast open you can see that enabled by using this command
There exist a number of open source projects trying to tackle accelerated file transfer via UDP. Some solutions are more mature than others and also use different technologies to solve the same problem of large data transfer over WAN. This article should provide the reader enough information to compare the different solutions and gauge if an open source project could be used instead of purchasing a commercial solution like FileCatalyst.
Some commercial managed file transfer solutions claiming to have UDP acceleration have integrated one of those open source projects into their core file transfer technology. These solutions will inherit the strengths but also the weaknesses of the open source project. FileCatalyst has developed its own UDP based protocol written from the ground up, and does not include any code from open source UDP technology.
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