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It is known that both iNOS and eNOS play a role in cardiac homeostasis [31]. Endothelial NOS is a constitutively expressed regulator of numerous essential cardiovascular functions, mainly responsible for mediation of vasodilation of blood vessels [32]. The activity of the enzyme depends not only on availability of all substrates and cofactors, but also it may be affected by posttranslational modification [31]. The most important of the regulatory eNOS phosphorylation sites is Ser1177, responsible for increasing eNOS activity by 2.5-fold [33]. The phosphorylation occurs in response to many different stimulus, oxidative stress among others [34].
Diesel's black sheep cousin, Gerwulf Grimoire, also wants the Stone. His motives are far from pure, and what he plans on doing with the treasure, no one knows...but Lizzy Tucker fears she's in his crosshairs. Never far and always watching, Grimoire has a growing, vested interest in the cupcake-baker-turned-finder-of-lost-things. As does another dangerous and dark opponent in the hunt - a devotee of lawlessness and chaos, known only as Anarchy.
The company was originally called Caw is Raw but only for a brief moment until Early 2009 when the name changed to YWE. The roster has become larger over the years so a brand split between SmackDown! and Raw was made allowing more viewing time for each superstar.
The YWE story begins in 2008 which was known as 'Caw is Raw' at the time. There were only wrestlers that featured were what we like to call now YWE originals like Mr. Black, Blue Star, Phenom, Grimez, etc. This season of YWE was filmed in very low quality as it had not established itself just yet. The Majority of 2008 was dominated by Mr. Black who was making a name for himself with the World Heavyweight Title at the time feuding with various people. Grimez was also a hot prospect in 2008 holding the Intercontinental Championship. When 2009 struck he was able to win the Royal Rumble and go on to win the World Heavyweight Championship from Blue Star who had won it from Mr. Black at the Rumble. After Wrestlefest (not Streamed) ended it was a new era in YWE as more caws began to get YouTube time. Grimez was the Heavyweight Champion, while Angel was the Intercontinental Champion, the Hardcore Champion was Phenom, and Tag Team Champions were New Mexicoolz. After 5 Months of not being champion, Mr. Black regained the World Heavyweight Championship at YWE Night Of Champions 2009 and from then on dominated 2009. He stumbled when he lost his title at Unforgiven in a 6 - pack challenge but then regained it Straight away at No Mercy. He then lost it again at the last PPV of 2009, Armageddon to Superstar B (Blue Star) who then went on to become the first Undisputed Heavyweight Champion of YWE after defeating The Rock the same night. Meanwhile, Thunder and Tornado formed the Power Trip and dominated the tag division until they split up at Armageddon after losing their titles to Newly formed Negrolution. Angel also held the Intercontinental title for the majority of 2009 his main rival was Icon who he defeated at Armageddon also.
2012 was an interesting year in YWE which saw tag teams break up and new tag teams formed. The Dark Angels and Bro Code Debuted this year while Justin James and Red Dread became a tag team. In the other direction, Negrolution and Mo' Money Broke up. Mr. Black won the 2012 Royal Rumble after a shock return at number 30 and went on to defeat Angel at Wrestlemania 3, After their feud it seemed that Angel and Mr. Black had some respect for one another. On the Other side Phenom finally reached the top of the food chain but his reign was overshadowed by the rise and dominance of Double D as he became a 2-time YWE champion tied with his brother Phsycoz. He has now become the longest-reigning YWE Champion after defeating Phenom at Summerslam. Towards the end of 2012, it seemed as though Mr. Black passed the torch to Angel and/or Victor X but not much has been read into this but Victor X thinks otherwise. Bro Code Debuted by attacking Fayth. They are only the 4th trio in YWE history. (Team Black out: 2008 - 2008) (RKO - Real Kaos Order: 2010 - 2011) (New Mexicoolz: 2008 - 2011). This year also saw the debut of Nightmare Kid and J.B. Rockin.
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