There is absolutely no configuration that you need to do to get it working. All you need to do is–install it, and start using it.
Since this is serverless, it is used in lot of the famous software that you are using, and you probably didn’t even know those software were using it. View this list to see all the big name companies who are using SQLite. PHP programming language has SQLite database built in.
If you’ve never used SQLite, follow the steps mentioned in this article to install it on Linux, and create a sample database.