Hi Charlie,
There appears to be some confusion here. COSMOS is its own software package (No programming language needed) and has nothing to do with the VXM driver. The VXM driver is a dll that wraps serial port functions to ease the use of the serial port to send and receive VXM commands.
That said, you do not have to use the driver, you could use Labview's VISA but then it would be on you as the programmer to understand the nuances of the serial port (such as knowing when there are characters to be read, and how many characters to read)
The most import parameters that you will need to know if not using the driver (Assuming the VXM is using factory defaults) are
Port: ---> Whatever Serial Port number you are connected to
Baud: 9600
Data Bits: 8
Parity: None
Stop Bits: 1
A good starting point using Labview Visa can be found at
National Instruments VISA and examples can be found in your Labview examples if you search for "Serial"