Welcome Student of ChE562

[Eric Jervis]

Instructor:
Eric Jervis
Department of Chemical Engineering
Bldg. E1, Rm. 2545
Email: eri...@cape.uwaterloo.ca
Newsgroup: uw.che.che562

Course Scope:
Concepts of transport phenomena, reactor engineering, and unit
operations are explored with respect to bioprocess design, optimization
and operation. Areas of application include biochemical, pharmaceutical
and waste treatment operations

Text:
Biochemical Engineering Fundamentals, 2nd Edition, J.E. Bailey and D.F.
Ollis, McGraw Hill, New York, 1986

Evaluation:
Term project Part I: 20 % (Due by Feb 20, 1998)
Part II: 30 % (Due by Mar 27, 1998)

Final Exam 50%

Suggested problems will be distributed during the course to provide
practice and illustrate important concepts. Solution sets will be
distributed one week after assignments are given. It is up to the
student to use these assignments to verify that they have understood
course material presented in class. Additional readings will be
provided to supplement course materials. Please use the Newsgroup to
discuss assignments, assigned readings and any other issues related to
the course.

Course Outline:

(1) Introduction – course business, student evaluation, term project
assignment

(2) Bioprocess overview – types of organisms (1.1-1.3), example
applications (12.5-12.8), current problems (6.4, 9.8), process economics
(12.1-12.4)

(3) Enzyme reaction engineering – reaction models (3.1, 3.4, 3.5),
kinetics and parameter estimation (3.2, 3.3), enzyme immobilization
(4.3, 4.4), enzyme activity modulation (3.6, 3.7)

(4) Fermentation kinetics – biomass production and substrate utilization
(7.1-7.3), product formation (7.5), parameter estimation (5.10), reactor
selection (9.7)

(5) Bioreactor design – ideal and multiphase bioreactors (9.1, 9.2,
9.6), instrumentation (10.1-10.3), sterilization (7.7, 8.11, 9.4),
‘open’ bioreactor systems (13.4, 14.3), process scale-up (8.9)

(6) Transport phenomena – mass transfer (8.1-8.7), non-Newtonian fluids
(8.8), mixing (9.3), heat transfer (8.10)

(7) Downstream processing – cell rupture and centrifugation (11.1),
precipitation (11.3), chromatography (11.4), membrane separations
(11.5), product stability

NB: numbers in parentheses refer to relevant sections in the text. Not
all topics will be discussed in class.

[S Cheung-Bret]

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