Physical Pharmaceutics 2 Book
Magdalena Liendo
Physical pharmacy is the branch of pharmacy that concentrates on the applications of physics and chemistry to the study of pharmacy. In other words, it is the study of the effects that dosage forms have on their environment by addressing issues at the molecular level.[1] It emphasis on the physical characteristics and actions of the drug delivery system before the same is given to the patient.[1] It forms the basis for design, manufacture, and distribution of drug products and serves as the foundation for the stable and proper use of medical drugs.[2] It covers areas such as solubility, pharmacokinetics and drug delivery.
Physical pharmacy serves as principles that guide the pharmaceutical developments.[2] It also serves as a basis for the understanding of drug absorptions, distributions, metabolism, and eliminations that happen during the course of drug treatment.[2]
All chapters are well illustrated and tables are clearly set out. Key points and clinical points are highlighted and readers are able to work through calculations and refer to the answers which can be found close by.
Since the first edition of the book was published 35 years ago, it has become a standard text for undergraduate and postgraduate pharmacy students in many parts of the world and by students of pharmaceutical sciences and other related disciplines. It fulfils an important requirement of describing the principles of physical pharmacy by using pharmaceutical examples to illustrate the topics.
PHM 8120 READINGS IN CNS DRUG DELIVERY
(1 credit) Professor Fairbanks
Weekly discussion of recent publications, methods and analyses relevant to research on delivery of drugs to the central nervous system. Offered concurrently with Phm 8481.
PHM 8220 PHYSICAL PHARMACY MODULE I
(1 credit) Professors Siegel, Suryanarayanan, and Sun
The first course in a two-course sequence which provides foundational materials in physical pharmacy for pharmaceutics graduate students.
PHM 8230 PHYSICAL PHARMACY MODULE II
(1 credit) Professors Siegel, Suryanarayanan, and Sun
The second course in a two-course sequence which provides foundational materials in physical pharmacy for pharmaceutics graduate students.
PHM/BMEN 8431 CONTROLLED DRUG AND GENE DELIVERY: MATERIALS, MECHANISMS AND MODELS
(4 credits) Professor Siegel
Physical, chemical, physiological, cell biological and mathematical principles underlying the design of delivery systems for drugs, including small molecules, proteins and genes.
PHM 8441 SOLUBILITY AND SOLID-STATE PROPERTIES OF DRUGS
(4 credits) Professors Suryanarayanan and Sun
Physical and physicochemical properties of drugs in solid state as related to drug delivery.
PHM/CMB/NSC 8481 ADVANCED NEUROPHARMACEUTICS
(4 credits) Professor Fairbanks
Delivery of compounds to the central nervous system to activate proteins in specific brain regions for therapeutic benefit. Pharmaceutical/pharmacological issues specific to direct drug delivery to the CNS.
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Remington Education: Physical Pharmacy provides a simple, concise view of the concepts and applications of physical pharmacy. It provides a summary of key information in the relevant subject area and includes cases and/or questions and answers for self-assessment, offering a practical way to check knowledge and track progress before, during, and after a course.
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A PhD in pharmaceutics is a research degree. While course work plays an important role, students become a real participant in the science of pharmaceutics in the laboratory. Faculty research covers a broad range of scientific interests, including pharmacokinetic toxicodynamics of anticancer agents, use of biomaterials and synthetic polymeric systems in design of drug delivery systems, passive and active targeting of therapeutic agents, cardiovascular targeting of drugs, novel delivery systems for proteins and peptides, and mathematical modeling of endogenous compounds.
The interdisciplinary option is intended to meet the needs of students interested in combining courses and skills from two areas of specialization. At least one of the specialization areas must come from within the college. The second area may come from a department in another college at Northeastern University, such as biology, chemistry, or engineering. Students electing the interdisciplinary option must fulfill the same requirements as all other PhD candidates.
BUILDS YOUR CAREER: Alumni employed by leading biotechnology companies such as Regeneron, Lonza Biotech, Pfizer, Endo, and Bayer as well as by cosmetic companies such as Estee Lauder, Avon, Shiseido, and others
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Students applying for admission to the M.S. in Pharmaceutics program with either specialization (Industrial Pharmacy or Cosmetic Science) must have an undergraduate degree in chemistry, biochemistry, biology, biological sciences, chemical engineering or pharmacy. For International students a minimum TOEFL score of 79 is required.
A presentation and analysis of recent developments in industrial pharmacy and pharmaceutics. Students are expected to present oral and written reports on a particular subject in consultation with the instructor in charge. May be repeated for credit.3 credits
A presentation and analysis of recent developments in cosmetic science. Students are expected to present oral and written reports on a particular cosmetic topic in consultation with the instructor in charge. Pass-Fail only.3 credits
The emphasis will be on chemical thermodynamics, from fundamental principles to applications in chemical equilibrium, including the concept of activity in nonideal systems, and electrochemistry of the pH electrode and other ion selective electrodes.3 credits
The emphasis of this course is on chemical kinetics, from experimental measurement of rate processes to activation theory and enzyme kinetics. Steady state activation theory will be included.3 credits
An introduction to basic pharmaceutical principles associated with pharmaceutical dosage forms. Discussions will focus on factors affecting dosage form design, manufacturing of different dosage forms, biopharmaceutics, pharmacokinetics, drug stability, FDA approvals and recalls, so that the student can obtain the knowledge needed to succeed in the M.S. and Ph.D. curricula. Waiver may be authorized by the division only.3 credits
A systematic study of the application of physico-chemical principles to the pharmaceutical and cosmetic sciences. Topics include complexation, colloids, interfacial phenomena, dissolution theory, suspensions, micromeritics and rheology.Prerequisite: Math 403 credits
An in-depth analysis of the chemical kinetics of pharmaceutical systems as applied to both in-vitro and in-vivo models. Drug decomposition, stabilization and storage of solutions, polyphasic systems and solids are emphasized.Prerequisite: PHS 9313 credits
A study of methods used to formulate, manufacture and stability-test various dosage forms including tablets, ointments, creams, capsules, suspensions, sterile products, etc. The different techniques used to formulate dosage forms possessing unique properties such as sustained or delayed release will also be covered.3 credits
A laboratory course designed to give students experience in utilizing industrial instrumentation to test basic principles and theories in the design and production of various dosage forms. Laboratory fee: $110.003 credits
Biopharmaceutic and pharmacokinetic principles, coupled with physical pharmacy concepts, are used to discuss methods necessary for optimizing the design of various drug-delivery systems. The course is intended for those having a basic understanding of dosage forms and their design, and is geared to the underlying principles of drug release from dosage forms. While a major portion of the course is devoted to oral solids, liquids, topical and parenteral design are also covered, together with means of evaluation and testing.3 credits
An introduction to basic engineering principles that are involved in the commercial manufacture of pharmaceutical dosage forms. Discussions will focus on how such principles as blending, mixing, heat and mass transfer are utilized to design and specify equipment used in producing powders, tablets, capsules and parenteral products. Basic concepts of cost estimation will also be discussed.3 credits
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