Dear Adam,
I cannot reproduce your issue: I have just updated my Windows 10 to the very latest, anti-virus updates etc, re-downloaded Uppaal 4.0.15 and everything runs fine.
I also tried scanning the disk using the default Windows malware protection tools, but it could not find anything.
Perhaps you could check if your files did not get modified somewhere along the way?
I attach a screenshot with CRC-32 sums of the files in bin-Win32 directory (you may need to add a new column "CRC-32" to see it in the zip archive).
A lighter check could be to see if the file sizes match.
(sorry for the huge screenshot, I could not make it smaller and still readable)
Best regards,
Marius
