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Gonzalo Pin Arboledas

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Jun 20, 2011, 1:42:41 AM6/20/11
to Unidad Valenciana del Sueño
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Ann Med. 2011 Jun 13. [Epub ahead of print]

Obesity and metabolic syndrome: Association with chronodisruption, sleep deprivation, and melatonin suppression.

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Department of Cellular and Structural Biology, UT Health Science Center , San Antonio, Texas USA.

Abstract

Abstract Obesity has become an epidemic in industrialized and developing countries. In 30 years, unless serious changes are made, a majority of adults and many children will be classified as overweight or obese. Whereas fatness alone endangers physiological performance of even simple tasks, the associated co-morbidity of obesity including metabolic syndrome in all its manifestations is a far more critical problem. If the current trend continues as predicted, health care systems may be incapable of handling the myriad of obesity-related diseases. The financial costs, including those due to medical procedures, absenteeism from work, and reduced economic productivity, will jeopardize the financial well-being of industries. The current review summarizes the potential contributions of three processes that may be contributing to humans becoming progressively more overweight: circadian or chronodisruption, sleep deficiency, and melatonin suppression. Based on the information provided in this survey, life-style factors (independent of the availability of abundant calorie-rich foods) may aggravate weight gain. Both epidemiological and experimental data support associations between disrupted physiological rhythms, a reduction in adequate sleep, and light-at-night-induced suppression of an essential endogenously produced molecule, melatonin. The implication is that if these problems were corrected with life-style changes, body-weight could possibly be more easily controlled.



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Gonzalo Pin Arboledas
Unidad Valenciana del Sueño
Hospital Quiron Valencia
www.uv-si.com
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