OLR

[Gonzalo Pin Arboledas]

Hola.
Parece interesante ............ pero no tengo el articulo completo. ¿Alguien de la lista lo puede conseguir?. Me imagino que los ÓLR

Gracias

Gonzalo

Arch Otolaryngol Head Neck Surg. 2011 Jun;137(6):576-82.

Effect of fluticasone furoate on interleukin 6 secretion from adenoid tissues in children with obstructive sleep apnea.

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Esteitie R., Emani J., Sharma S., Suskind D.L., Baroody F.M.

Section of Otolaryngology-Head and Neck Surgery, The University of Chicago Medical Center, 5841 S Maryland Ave, Mail Code 1035, Chicago, IL 60637. fbar...@surgery.bsd.uchicago.edu.

OBJECTIVE: To determine the effect of intranasal corticosteroid therapy on T-regulatory cells and other inflammatory cytokines in adenoid tissues in children with obstructive sleep apnea syndrome. DESIGN: Randomized, prospective, exploratory study. SETTING: Academic pediatric otolaryngology practice in a tertiary care children's hospital. PATIENTS: Participants included 24 children between the ages of 2 and 12 years who were undergoing adenotonsillectomy for polysomnogram-documented obstructive sleep apnea syndrome. INTERVENTION: Children were randomized to either no treatment (n = 13) or treatment with fluticasone furoate nasal spray, 55 mug/nostril daily (n = 11), for 2 weeks before adenotonsillectomy. Adenoid tissue was obtained at the time of the procedure. MAIN OUTCOME MEASURES: The number of tissue T-regulatory cells, as determined by staining with FOXP3, CD4, and CD25, was the primary outcome measure. Staining for interleukin (IL)-10 and transforming growth factor-beta protein by immunohistochemistry, and adenoid mononuclear cell spontaneous and induced release of cytokines (IL-10, IL-6, IL-12, IL-13, tumor necrosis factor, and transforming growth factor beta) were secondary outcomes. RESULTS: Cells isolated from fluticasone furoate nasal spray-treated adenoid tissue released significantly less IL-6 spontaneously as well as upon stimulation with anti-CD3 monoclonal antibody (P = .05) compared with nontreated adenoid tissue. There were no significant differences in the number of CD4/FOXP3-, CD25/FOXP3-, or transforming growth factor beta-positive cells. Intensity of staining for IL-10 was also comparable between the groups. CONCLUSIONS: In this study, we show reduction of IL-6, a proinflammatory cytokine, in adenoid tissue obtained from children with obstructive sleep apnea syndrome treated with fluticasone furoate nasal spray. This reduction could contribute to the clinical efficacy of this class of medications in the treatment of childhood obstructive sleep apnea syndrome.

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Gonzalo Pin Arboledas
Unidad Valenciana del Sueño
Hospital Quiron Valencia
www.uv-si.com

[Eduard Esteller]

Te lo miro el lunes, Gonzalo

Eduard Esteller

2011/6/24 Gonzalo Pin Arboledas <pinarbole...@gmail.com>

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[Gonzalo Pin Arboledas]

Gracias.... .realmente era una indirecta muy directa.

Gonzalo

2011/6/24 Eduard Esteller <eest...@gmail.com>