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Age-related Iron Accumulation In Progressive Multiple Sclerosis
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ironjustice
Mar 19, 2015, 6:23:48 AM3/19/15
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Pathological mechanisms in progressive multiple sclerosis.
Mahad DH1, Trapp BD2, Lassmann H3.
Lancet Neurol. 2015 Feb;14(2):183-193.
Abstract
A better understanding of the pathological mechanisms that drive neurodegeneration in individuals with multiple sclerosis is needed to develop therapies that will effectively treat patients in the primary and secondary progressive stages of the disease.
We propose that the inflammatory demyelinating disease process in early multiple sclerosis triggers a cascade of events that lead to neurodegeneration and are amplified by pathogenic mechanisms related to brain ageing and accumulated disease burden.
Key elements driving neurodegeneration include microglia activation, chronic oxidative injury, accumulation of mitochondrial damage in axons, and age-related iron accumulation in the human brain.
Altered mitochondrial function in axons might be of particular importance.
This process leads to chronic cell stress and imbalance of ionic homoeostasis, resulting in axonal and neuronal death.
The evidence suggests that treatment of progressive multiple sclerosis should be based on a combination of anti-inflammatory, regenerative, and neuroprotective strategies.
doi: 10.1016/S1474-4422(14)70256-X.
Copyright © 2015 Elsevier Ltd. All rights reserved.
PMID: 25772897
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Mahad DH1, Trapp BD2, Lassmann H3.
Lancet Neurol. 2015 Feb;14(2):183-193.
Abstract
A better understanding of the pathological mechanisms that drive neurodegeneration in individuals with multiple sclerosis is needed to develop therapies that will effectively treat patients in the primary and secondary progressive stages of the disease.
We propose that the inflammatory demyelinating disease process in early multiple sclerosis triggers a cascade of events that lead to neurodegeneration and are amplified by pathogenic mechanisms related to brain ageing and accumulated disease burden.
Key elements driving neurodegeneration include microglia activation, chronic oxidative injury, accumulation of mitochondrial damage in axons, and age-related iron accumulation in the human brain.
Altered mitochondrial function in axons might be of particular importance.
This process leads to chronic cell stress and imbalance of ionic homoeostasis, resulting in axonal and neuronal death.
The evidence suggests that treatment of progressive multiple sclerosis should be based on a combination of anti-inflammatory, regenerative, and neuroprotective strategies.
doi: 10.1016/S1474-4422(14)70256-X.
Copyright © 2015 Elsevier Ltd. All rights reserved.
PMID: 25772897
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
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