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Paracetamol
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Fevric J. Glandules
May 12, 2013, 9:07:51 PM5/12/13
to
Best invention of the 20th century.
Discuss.
Discuss.
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Fevric J. Glandules
May 14, 2013, 11:23:17 AM5/14/13
to
Patrick Hardlentil wrote:
> And "Fevric J. Glandules" <f...@invalid.invalid> was like:
>
> Trick question?
Yebbut it wasn't "invented" as a general purpose painkiller until
the 1940s. OSLT. In the same way that all sorts of places were
"discovered" in the 19th century that had been there all along.
No?
> And "Fevric J. Glandules" <f...@invalid.invalid> was like:
>
>> Best invention of the 20th century.
>
> First synthesised 1878.
>> Best invention of the 20th century.
>
>
> Trick question?
Yebbut it wasn't "invented" as a general purpose painkiller until
the 1940s. OSLT. In the same way that all sorts of places were
"discovered" in the 19th century that had been there all along.
No?
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Willy Eckerslyke
May 15, 2013, 11:43:49 AM5/15/13
to
It's no good in the jungle, of course.
Bod
May 15, 2013, 11:52:42 AM5/15/13
to
On 15/05/2013 16:43, Willy Eckerslyke wrote:
> It's no good in the jungle, of course.
>
Yup. Those damn parrots!
> It's no good in the jungle, of course.
>
Steve Terry
May 16, 2013, 2:27:56 AM5/16/13
to
Fevric J. Glandules wrote:
> Best invention of the 20th century.
> Discuss.
>
Yep, take a handful and you'll destroy your liver giving you an agonisingly
> Best invention of the 20th century.
> Discuss.
>
slow death
Steve Terry
--
Get a free GiffGaff PAYG Sim and �5 bonus after activation at:
http://giffgaff.com/orders/affiliate/gfourwwk
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Mustaffa Burke
May 16, 2013, 3:47:17 PM5/16/13
to
"Fevric J. Glandules" wrote in message news:kmped7$ppp$1...@dont-email.me...
>Best invention of the 20th century.
>
Invented by the Greeks 776 BC
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Fevric J. Glandules
May 16, 2013, 7:37:02 PM5/16/13
to
Patrick Hardlentil wrote:
>
> And Marc Wilson <E-0C0013...@cleopatra.co.uk> was like:
>
>> There's another chemical you can add to paracetamol that prevents the
>> liver damage. I can't offhand remember what it's called. In some other
>> countries, it's routinely added to tablets, and in a few it's mandatory.
>>
>> But the UK pharma industry have campaigned against its use.
>
> You must admit, that sounds a bit man-in-the-pubby.
>
> But I have no facts to set against it.
>
http://www.bmj.com/content/315/7103/301
>
> And Marc Wilson <E-0C0013...@cleopatra.co.uk> was like:
>
>> There's another chemical you can add to paracetamol that prevents the
>> liver damage. I can't offhand remember what it's called. In some other
>> countries, it's routinely added to tablets, and in a few it's mandatory.
>>
>> But the UK pharma industry have campaigned against its use.
>
> You must admit, that sounds a bit man-in-the-pubby.
>
> But I have no facts to set against it.
>
http://www.bmj.com/content/315/7103/301
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Stephen Wolstenholme
May 17, 2013, 4:47:12 AM5/17/13
to
On Fri, 17 May 2013 02:50:18 +0100, Marc Wilson
<E-0C0013...@cleopatra.co.uk> wrote:
>In uk.misc, (Patrick Hardlentil) wrote in
><86bo8aw...@dogslobber.demon.co.uk>::
>phrase to Google it, I'll let you know.
>
>Ah!
>
>Methionine. That's the stuff.
>
>http://en.wikipedia.org/wiki/Paracetamol_poisoning#Treatment
>
>There's a proprietary drug which combines paracetamol and methionine,
>called Paradote.
Methionine is difficult to double blind test because it would require
some people to get liver damage. The drug companies will not risk such
testing. It easier and cheaper just to put a warning on packs of
Paracetamol.
Steve
--
EasyNN-plus. Neural Networks plus. http://www.easynn.com
SwingNN. Forecast with Neural Networks. http://www.swingnn.com
JustNN. Just Neural Networks. http://www.justnn.com
<E-0C0013...@cleopatra.co.uk> wrote:
>In uk.misc, (Patrick Hardlentil) wrote in
><86bo8aw...@dogslobber.demon.co.uk>::
>
>>
>>And Marc Wilson <E-0C0013...@cleopatra.co.uk> was like:
>>
>>> There's another chemical you can add to paracetamol that prevents the
>>> liver damage. I can't offhand remember what it's called. In some other
>>> countries, it's routinely added to tablets, and in a few it's mandatory.
>>>
>>> But the UK pharma industry have campaigned against its use.
>>
>>You must admit, that sounds a bit man-in-the-pubby.
>>
>>But I have no facts to set against it.
>
>If I can remember what the damned stuff is called, or pick the right
>>
>>And Marc Wilson <E-0C0013...@cleopatra.co.uk> was like:
>>
>>> There's another chemical you can add to paracetamol that prevents the
>>> liver damage. I can't offhand remember what it's called. In some other
>>> countries, it's routinely added to tablets, and in a few it's mandatory.
>>>
>>> But the UK pharma industry have campaigned against its use.
>>
>>You must admit, that sounds a bit man-in-the-pubby.
>>
>>But I have no facts to set against it.
>
>phrase to Google it, I'll let you know.
>
>Ah!
>
>Methionine. That's the stuff.
>
>http://en.wikipedia.org/wiki/Paracetamol_poisoning#Treatment
>
>There's a proprietary drug which combines paracetamol and methionine,
>called Paradote.
Methionine is difficult to double blind test because it would require
some people to get liver damage. The drug companies will not risk such
testing. It easier and cheaper just to put a warning on packs of
Paracetamol.
Steve
--
EasyNN-plus. Neural Networks plus. http://www.easynn.com
SwingNN. Forecast with Neural Networks. http://www.swingnn.com
JustNN. Just Neural Networks. http://www.justnn.com
Steve Firth
May 17, 2013, 8:32:49 AM5/17/13
to
Stephen Wolstenholme <eas...@googlemail.com> wrote:
> On Fri, 17 May 2013 02:50:18 +0100, Marc Wilson
> <E-0C0013...@cleopatra.co.uk> wrote:
>
>> In uk.misc, (Patrick Hardlentil) wrote in
>> <86bo8aw...@dogslobber.demon.co.uk>::
>>
>>>
>>> And Marc Wilson <E-0C0013...@cleopatra.co.uk> was like:
>>>
>>>> There's another chemical you can add to paracetamol that prevents the
>>>> liver damage. I can't offhand remember what it's called. In some other
>>>> countries, it's routinely added to tablets, and in a few it's mandatory.
>>>>
>>>> But the UK pharma industry have campaigned against its use.
>>>
>>> You must admit, that sounds a bit man-in-the-pubby.
>>>
>>> But I have no facts to set against it.
>>
>> If I can remember what the damned stuff is called, or pick the right
>> phrase to Google it, I'll let you know.
>>
>> Ah!
>>
>> Methionine. That's the stuff.
>>
>> http://en.wikipedia.org/wiki/Paracetamol_poisoning#Treatment
>>
>> There's a proprietary drug which combines paracetamol and methionine,
>> called Paradote.
>
> Methionine is difficult to double blind test because it would require
> some people to get liver damage. The drug companies will not risk such
> testing. It easier and cheaper just to put a warning on packs of
> Paracetamol.
There have been trial proposals in the past, for paracetamol
> On Fri, 17 May 2013 02:50:18 +0100, Marc Wilson
> <E-0C0013...@cleopatra.co.uk> wrote:
>
>> In uk.misc, (Patrick Hardlentil) wrote in
>> <86bo8aw...@dogslobber.demon.co.uk>::
>>
>>>
>>> And Marc Wilson <E-0C0013...@cleopatra.co.uk> was like:
>>>
>>>> There's another chemical you can add to paracetamol that prevents the
>>>> liver damage. I can't offhand remember what it's called. In some other
>>>> countries, it's routinely added to tablets, and in a few it's mandatory.
>>>>
>>>> But the UK pharma industry have campaigned against its use.
>>>
>>> You must admit, that sounds a bit man-in-the-pubby.
>>>
>>> But I have no facts to set against it.
>>
>> If I can remember what the damned stuff is called, or pick the right
>> phrase to Google it, I'll let you know.
>>
>> Ah!
>>
>> Methionine. That's the stuff.
>>
>> http://en.wikipedia.org/wiki/Paracetamol_poisoning#Treatment
>>
>> There's a proprietary drug which combines paracetamol and methionine,
>> called Paradote.
>
> Methionine is difficult to double blind test because it would require
> some people to get liver damage. The drug companies will not risk such
> testing. It easier and cheaper just to put a warning on packs of
> Paracetamol.
co-administered with acetylcysteine. Methionine, used in Paradote, is an
older "antidote" for paracetamol poisoning, Acetylcysteine has been the
therapy of choice for what feels like forever - 1970s onwards. I suspect
they chose Methionine because it's not as vile tasting as Acetylcysteine.
These trials have not foundered on ethics, button cost. You don't have to
watch someone suffer liver damage, it's possible to assess the efficacy of
the drug at therapeutic doses. It's possible to quantify serum paracetamol
and to determine biochemical markers of liver toxicity (AST, ALT and
bilirubin) at doses below a lethal dose.
Anyway, the real reason for not doing anything is because makers want to
sell cheap to make tablets at as high a price as possible while keeping
costs to a minimum. If rationality came into it paracetamol would be
banned. It kills more people from acute liver failure than alcohol.
--
<•DarWin><|
_/ _/
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Marcus Houlden
May 17, 2013, 11:43:59 AM5/17/13
to
On Fri, 17 May 2013 12:32:49 +0000 (UTC), Steve Firth <%steve%@malloc.co.uk>
wrote the following to uk.misc:
> Anyway, the real reason for not doing anything is because makers want to
> sell cheap to make tablets at as high a price as possible while keeping
> costs to a minimum. If rationality came into it paracetamol would be
> banned. It kills more people from acute liver failure than alcohol.
I remember the days before the rules on package sizes, when you could buy a
bottle of 100 paracetamol tablets for less than a pound. That was in the mid
to late 90s, but even allowing for inflation the cost per tablet is a lot
higher than it used to be.
mh.
--
http://www.nukesoft.co.uk
http://www.houlden.org
wrote the following to uk.misc:
> Anyway, the real reason for not doing anything is because makers want to
> sell cheap to make tablets at as high a price as possible while keeping
> costs to a minimum. If rationality came into it paracetamol would be
> banned. It kills more people from acute liver failure than alcohol.
bottle of 100 paracetamol tablets for less than a pound. That was in the mid
to late 90s, but even allowing for inflation the cost per tablet is a lot
higher than it used to be.
mh.
--
http://www.nukesoft.co.uk
http://www.houlden.org
Richard Tobin
May 17, 2013, 12:03:44 PM5/17/13
to
In article <slrnkpck9...@neutron.nukesoft.co.uk>,
since 1996, so that's equivalent to 46p in 1996. Or about 150p for a
hundred at 1996 prices. So it's higher, but not enormously so.
-- Richard
Marcus Houlden <mh-...@nukesoft.co.uk> wrote:
>I remember the days before the rules on package sizes, when you could buy a
>bottle of 100 paracetamol tablets for less than a pound. That was in the mid
>to late 90s, but even allowing for inflation the cost per tablet is a lot
>higher than it used to be.
A packet of 32 costs 69p from Boots. Prices have increased by 50%
>I remember the days before the rules on package sizes, when you could buy a
>bottle of 100 paracetamol tablets for less than a pound. That was in the mid
>to late 90s, but even allowing for inflation the cost per tablet is a lot
>higher than it used to be.
since 1996, so that's equivalent to 46p in 1996. Or about 150p for a
hundred at 1996 prices. So it's higher, but not enormously so.
-- Richard
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Fevric J. Glandules
May 17, 2013, 7:12:29 PM5/17/13
to
Huge wrote:
> On 2013-05-17, Marc Wilson <E-0C0013...@cleopatra.co.uk> wrote:
>>
>> I am firmly of the opinion that it's a human right to decide when you've
>> had enough, despite what the god-botherers say.
>
> +1
It follows that one should have a working knowledge of the less painful
methods, given that at the time of (self-)execution one is not likely
to be entirely compos mentis.
So what is it? Hosepipe?
> On 2013-05-17, Marc Wilson <E-0C0013...@cleopatra.co.uk> wrote:
>>
>> I am firmly of the opinion that it's a human right to decide when you've
>> had enough, despite what the god-botherers say.
>
> +1
It follows that one should have a working knowledge of the less painful
methods, given that at the time of (self-)execution one is not likely
to be entirely compos mentis.
So what is it? Hosepipe?
Fevric J. Glandules
May 17, 2013, 7:16:24 PM5/17/13
to
Patrick Hardlentil wrote:
> Curse you and your facts. Next you'll be telling me cars really could
> run on water if it weren't for them truth-suppressing oil companies.
My experimental Universal Knowledge Machine has digested your input
and told me that all oil companies are French.
Some tweaks appear to be needed.
> Curse you and your facts. Next you'll be telling me cars really could
> run on water if it weren't for them truth-suppressing oil companies.
My experimental Universal Knowledge Machine has digested your input
and told me that all oil companies are French.
Some tweaks appear to be needed.
Steve Terry
May 18, 2013, 1:36:46 AM5/18/13
to
Marc Wilson wrote:
> In uk.misc, (Patrick Hardlentil) wrote in
> <86li7ew...@dogslobber.demon.co.uk>::
> In uk.misc, (Patrick Hardlentil) wrote in
>>> In uk.misc, (Steve Terry) wrote in <kn1u22$vbt$1...@dont-email.me>::
>>>
>>>> Fevric J. Glandules wrote:
>>>>> Best invention of the 20th century.
>>>>> Discuss.
>>>>>
>>>> Yep, take a handful and you'll destroy your liver giving you an
>>>> agonisingly slow death
>>>
>>> Only because the pharmacorps won't spend 0.1p per tablet making it
>>>> Fevric J. Glandules wrote:
>>>>> Best invention of the 20th century.
>>>>> Discuss.
>>>>>
>>>> Yep, take a handful and you'll destroy your liver giving you an
>>>> agonisingly slow death
>>>
>>> safe.
>>
>> Wossat all about, then?
>
> There's another chemical you can add to paracetamol that prevents the
> liver damage. I can't offhand remember what it's called. In some
> other countries, it's routinely added to tablets, and in a few it's
> mandatory.
>
> But the UK pharma industry have campaigned against its use.
>
Paradote, available as a paracetamol substitute in many other countries
> There's another chemical you can add to paracetamol that prevents the
> liver damage. I can't offhand remember what it's called. In some
> other countries, it's routinely added to tablets, and in a few it's
> mandatory.
>
> But the UK pharma industry have campaigned against its use.
>
But not here as that would admit there's a problem.
Recent statistics showed more die in the UK from Paracetamol than Heroin
Ironically we spend �millions on the war on drugs, when a simple change
in the law which many other countries already have done would save far more
lives!
Seems we have the best Politicians money can buy ;-p
It's a funny old world
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