Not done exactly that, but I made up an adaptor once to clamp the spigot
with an O ring into a matching hole using stepped fingers bolted into
place. Details are irrelevant, but it needed careful fettling of parts
so that the clamps were effective. As you obviously know, the forces on
the joining pieces will be large so you need very mechanically sound
fittings.
I think the limitation in your case might be the double eared O clamps.
They are only retaining a few bar on things like LPG cylinders, etc.
It might be worth looking for a company which makes custom hydraulic
hoses, who will have proper heavy duty crimps in every possible size,
and the hardware to fix them. I don't think they would charge silly
money to crimp to your joining pieces. They might even have suitable
replacement hose which they could fit to your existing fittings, or
perhaps ready made joining pieces.