Re: Oxygen Not Included Mobile
Latrisha Adan
These 2 years companies are releasing mobiles with better hardware, so it can run some really good games from PC, so I thought if is here some plan of releasing Oxygen not included on mobile, when and or why not?
And with the DLC giving you multiple simultaneously running colonies I'm also gonna go out on a limb and say IF we ever get a mobile version of ONI, it's most likely gonna be severely cut down version of the main game. I mean quadruple amputee levels of cut down: large amounts of content would probably have to be completely altered or outright removed to cram it onto mobile skews.
I think people just keep severely overestimating what phones can do. A phone is basically not much more than the minimum required to run a "real" OS, with more memory. It is in no way equal to a modern PC. Without extensive GPU use, it would be dog-slow. For example, the main memory bandwidth of a current high-end phone is around 10GB/s or so. A modern PC has around 50GB/s. Caches on the phone are slower, smaller and have lower associativity. Pipelines are shorter. Buffers have less capacity. Buses are smaller. IPC is lower. Clock is lower. And so on.
They can't solve the lag on pc. And you want a mobile version? How about we fix the pc version first then talk mobile. One more thing battery drain you won't be playing more than 5 cycles without a cable to an outlet.
Main problem here is interface which is not designed to run on touch devices and this one is not easy to skip on final product.
Any way I dont see benefit of playing game like oni on tiny screen. Maybe it would be fun if our colony runs on 24h and we could do checks on our dupes like ants in aquarium.
Another game in the style and the ONI universe is possible. Like the Fallout shelter in the falllout universe.
But Klei prefers to make games each time in a different style, a different universe and with different mechanics, rather than a series of similar games.
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Background: In recent times there has been some controversy over the impact of electromagnetic radiation on human health. The significance of mobile phone radiation on male reproduction is a key element of this debate since several studies have suggested a relationship between mobile phone use and semen quality. The potential mechanisms involved have not been established, however, human spermatozoa are known to be particularly vulnerable to oxidative stress by virtue of the abundant availability of substrates for free radical attack and the lack of cytoplasmic space to accommodate antioxidant enzymes. Moreover, the induction of oxidative stress in these cells not only perturbs their capacity for fertilization but also contributes to sperm DNA damage. The latter has, in turn, been linked with poor fertility, an increased incidence of miscarriage and morbidity in the offspring, including childhood cancer. In light of these associations, we have analyzed the influence of RF-EMR on the cell biology of human spermatozoa in vitro.
Principal findings: Purified human spermatozoa were exposed to radio-frequency electromagnetic radiation (RF-EMR) tuned to 1.8 GHz and covering a range of specific absorption rates (SAR) from 0.4 W/kg to 27.5 W/kg. In step with increasing SAR, motility and vitality were significantly reduced after RF-EMR exposure, while the mitochondrial generation of reactive oxygen species and DNA fragmentation were significantly elevated (P
Conclusions: RF-EMR in both the power density and frequency range of mobile phones enhances mitochondrial reactive oxygen species generation by human spermatozoa, decreasing the motility and vitality of these cells while stimulating DNA base adduct formation and, ultimately DNA fragmentation. These findings have clear implications for the safety of extensive mobile phone use by males of reproductive age, potentially affecting both their fertility and the health and wellbeing of their offspring.
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Enzymatic Biofuel cells (EBC) are device that converts chemical energy into electrical energy using (i) enzyme as biocatalysts and (ii) glucose/alcohol as biofuels since it was reported in 19641,2. The EBC has unique advantages like low-temperature operation, neutral pH, lower maintenance and operation cost and selective catalytic activity. Furthermore, the EBC may well use glucose and oxygen included in human body as its fuel sources1,3,4. In spite of that, it has still several issues to address such as low electrical performance, short long-term stability, use of still expensive membrane and large fuel cell size for embedding inside human body. Enzyme deactivation and denaturation have been already reported as evidences of the drawbacks related to performance and stability of EBC while it is probably that membrane placed in between two electrodes is a main reason for cost increase and size enlargement of the fuel cell system. Such potentially possible problems can be solved by enhancing enzyme immobilization, discovering more appropriate enzyme catalysts and removing the membrane in fuel cell system4,5,6,7,8,9.
Regarding the enzyme immobilization strategy, although physical adsorptions like physical entrapment and chemical bonding like covalent coupling and enzyme cross-linking were attempted, using Layer-by-Layer (LbL) has been recently emerged. According to the LbL structure, (i) multiple repetitive layers are stack together by electrostatic interaction between oppositely charged species and (ii) the stack layers are formed on the nano-sized supporters like carbon nanotube (CNT)2,10,11,12,13.
As the possible enzyme catalysts, glucose oxidase (GOx) catalyzing glucose oxidation and laccase (Lac) catalyzing oxygen reduction have been considered14,15. In case of GOx, its relatively large electromotive force and strong compatibility with human body are main advantages while in terms of laccase, its capability catalyzing four electron reduction reactions from O2 to H2O without production of intermediate H2O2 can be considered the merit16.
To fabricate the viable enzyme-included LbL catalysts, using proper conducting polymer (CP) and/or cross-linker can be affordable option. In this study, poly(ethylenimine) (PEI), glutaraldehyde (GA) and CNT were used as the CP17,18, cross-linker and supporter, respectively. Regarding PEI, it is charged positively, whereas enzyme molecules and CNT are negatively charged. Such an opposite polarity makes bonding among them strong by electrostatic interaction19,20. As for cross-linker, GA induces polymerization amid GA and LbL consisting of enzyme/CP/supporter by cross-linking reaction (aldol condensation reaction). As a result, strong covalent bonds (C=N bonds) are formed in between them21.
Regarding cost and size of EBC system, optimizing role of membrane included in the EBC may be critical. For doing that, we evaluate two things; first, inspecting optimal membrane thickness and second, removing membrane although the latter is likely to be more effective because the removal of membrane can reduce the size and cost of EBC in a more straightforward way. The membrane usually plays two different roles as separator (i) to alleviate occurrence of mixed potential and (ii) to increase ohmic resistance so that it should be designed (i) what is appropriate membrane thickness if the membrane is utilized and (ii) how to modulate associated parameters if membrane is not used.
In this study, we fabricate EBC system using (i) anode consisting of GA/[[GOx/PEI]2/CNT] biocatalyst that is an enzyme structure based on our previous research for glucose oxidation reaction (GOR) and (ii) cathode consisting of three different biocatalysts including GA, Lac, PEI and CNT for oxygen reduction reaction (ORR)22. Schematic illustrations indicating enzyme structures of anode and cathode are represented in Fig. 1. Using the enzyme structures, effect of Nafion 117 membrane on EBC performance is initially evaluated and then performances of mediatorless/membraneless EBCs relying on four important parameters are overhauled with quantification of EBC performance by using electrochemical characterizations such as polarization curves and electrochemical impedance spectroscopy (EIS). For measuring them, new EBC kit is designed and Fig. 2 presents photo images and schematic illustrations of the new EBC kit. With that, we anticipate that our study will contribute to establish baseline protocols of mediatorless/membraneless EBC system.
It is also important to investigate whether our enzyme catalysts can work well for a long time. To evaluate the long term stability of enzyme catalysts, catalytic activities of the enzyme catalysts were measured every week for four weeks and the results are represented in Fig. S4a (GA/[[GOx/PEI]2/CNT] catalyst for anode) and Fig. S4b (Lac/CNT, Lac/PEI/Lac/CNT and GA/[Lac/PEI/Lac/CNT] catalysts for cathode). For the Fig. S4a, FAD redox reaction peak of GA/[[GOx/PEI]2/CNT] catalyst was measured, while cupric ion redox reaction peaks of Lac-based catalysts were measured for the Fig. S4b.
According to the Figs S4a,b, the peak current density of GA/[[GOx/PEI]2/CNT] catalyst was maintained to 87% of initial value, while those of Lac-based catalysts were maintained to 89, 75 and 64% of initial value. It can be explained that (i) long term stabilities of all the catalysts are better than that of other similar catalysts, implying that EBCs adopting these catalysts may also keep their stabilities22,32 and (ii) long term stability of the GA/[Lac/PEI/Lac/CNT] catalyst is best, anticipating that EBC adopting this catalyst will be mostly stable. Taken together, performance and stability measurements of EBCs including membrane between anode and cathode electrodes show that EBC adopting GA/[Lac/PEI/Lac/CNT] catalyst sheds light on promising result.
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