I mean, amiable as he is, I won't be getting up at 3am to watch Mulaney's, or anybody's, comedy specials.
To the best of my knowledge, only one Netflix live event has really troubled a mostly-non-US timezone so far. Their "Netflix Slam" tennis match aired in European primetime - I think it took place in Vegas at noon local time/3pm EST. But I didn't really have a reason to watch a non-competitive tennis match ahead of, I don't know, an actual sports fixture that counts for something. I did tune in for a few minutes out of interest, and was mostly amused that one of their courtside interviewers was being shushed by her interviewee because she was continuing to ask questions as one of the players tried to serve. I didn't recognise any of the people involved but they might have been sportsmen/women?
Amusingly, in my Netflix queue, the match is still there as something for me to go back to and finish.
Adam