Hi Lin,
1. In TVB WEB GUI, you can alter the Large Scale Connectivity matrices, by changing edge values and save the edited form as a new Connectivity. You can not change the original Connectivity DataType itself and persist in the same entity. The reason we choose this implementation, is for preserving reproducibility. Operations launched with the initial state, should remain consistent. Also linked TimeSeries on the original Connectivity need it to remain intact.
2. You should be able to edit a previously edited Connectivity multiple times (and save multiple copies).
In case your scenario is not to cut nodes, but preserve all original nodes, and just alter connections, I suggest you use the most right button to save the new entity, as it will also recreate the linked entities (like the RegionMapping).
Best,
Lia.