Convert empirical BOLD to firing rate and membrane potential for tvb.simulation.inital_conditions

[Josh Neudorf]

Hello,

I would like to be able to set initial conditions (firing rate and membrane potential) for a TVB model based on empirical BOLD data we have in order to observe the dynamics that follow from these initial conditions.

I realize that there would be multiple solutions for this mapping but if if we set some constraints/assumptions we should be able to constrain the problem space: for example, assume that the HRF has peaked and that firing rate and membrane potential are constant.

Would someone be able to provide a suggestion for how to calculate this reverse mapping in a way that is consistent with how the monitor produces BOLD from firing rate and membrane potential?

Much appreciated,

Josh

[WOODMAN Michael]

hi,

I think the easiest approach would be to run several short simulations with the steady state assumption you mention, check the BOLD values you get, varying the parameters and initial conditions until you have coverage of the range of BOLD values you observe empirically.

cheers,

Marmaduke

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From: tvb-...@googlegroups.com <tvb-...@googlegroups.com> on behalf of Josh Neudorf <josh.n...@usask.ca>
Sent: Wednesday, May 22, 2024 7:34:38 PM
To: TVB Users
Subject: [RESEAUX SOCIAUX] [TVB] Convert empirical BOLD to firing rate and membrane potential for tvb.simulation.inital_conditions

 

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[Josh Neudorf]

Hello,

Thank you for your response, this suggestion could work. How would I configure the model to maintain a constant firing rate and membrane potential rather than simulating dynamics based on one of the models?

Thanks again,

Josh

[WOODMAN Michael]

hi

that depends on the model.  Some models like the Reduced Wong-Wang only have fixed points, so that would be a place to start.

cheers,

Marmaduke

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From: tvb-...@googlegroups.com <tvb-...@googlegroups.com> on behalf of Josh Neudorf <josh.n...@usask.ca>

Sent: Thursday, May 23, 2024 7:35:02 PM
To: TVB Users
Subject: [RESEAUX SOCIAUX] Re: [RESEAUX SOCIAUX] [TVB] Convert empirical BOLD to firing rate and membrane potential for tvb.simulation.inital_conditions

 

To view this discussion on the web visit https://groups.google.com/d/msgid/tvb-users/1510dbd3-16b3-4218-a652-b22e750043ddn%40googlegroups.com.