Solver for Neurotransmitter dependencies -possible in TVB?

[Ulrich Brennecke]

Dear all,

I am looking for a way to simulate neurotransmitter changes in the brain using a kind of “solver”.
Very roughly and schematically formulated:
- Drug 1 increases extracellular dopamine in the PFC
- Increased extracellular dopamine in the PFC decreases extracellular dopamine in the dorsal striatum
- Decreased extracellular dopamine in the dorsal striatum in turn has its own vectors on other neurotransmitters in other brain regions
- ...

Is it possible in principle to map such influence vectors in TVB and build a network of data sets to see the influences of the change of one value on other values?

If TVB cannot do this, I would be grateful for a hint as to which technique could be used to realize such a solver.
Thank you very much!

[WOODMAN Michael]

hi,

If I can restate your question, you have a per-region parameter of extracellular dopamine, that you want to change over time to see the effects.  That's in principle possible in TVB yes.  

> in turn has its own vectors on other neurotransmitters in other brain regions

I don't know what this means, maybe you can clarify that part?

cheers,

Marmaduke

---

From: tvb-...@googlegroups.com <tvb-...@googlegroups.com> on behalf of Ulrich Brennecke <in...@adxs.org>
Sent: Sunday, March 30, 2025 3:05:40 AM
To: TVB Users
Subject: [RESEAUX SOCIAUX] [TVB] Solver for Neurotransmitter dependencies -possible in TVB?

 

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