Question about mouse brain resting-state simulation parameter

[Jeehye An]

Hi, I have a question about TVB mouse brain resting-state simulation pipeline from EBRAINS collabs (link). 

In Part 1, it shows that I_o (external input) = 0.322 puts the system in a bistable regime, whereas I_o = 0.3 or 0.35 puts it in a monostable regime. 

However, in part 2, it proceeds with an I_o value of 0.3 (instead of 0.322) for simulating a multistable regime. I'm confused why, could someone explain? Thank you! 

[Julie Courtiol]

Hi,

In part I, we are simulating an uncoupled system (one isolated node), while in part II, we are simulating a coupled system (network). The input of the remote activities, scaled by the parameter G, is pushing the system closer to the bifurcation: the global input value is then higher, and might switch the system in the monostable regime (>0.35). We should use a smaller I_0 value compared with an uncoupled system to be in a multistable state.

Best,

Julie

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Best regards,

Dr. Julie Courtiol

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