Enabling "Flush DNS cache after connecting or disconnecting" under Tunnelblick 3.8.5a kills mDNSResponderHelper under Big Sur 11.3 after connecting or disconnecting, e.g., from /var/log/system.log,
May 1 13:01:11 Stuart-laptop com.apple.xpc.launchd[1] (com.apple.mDNSResponderHelper.reloaded[8442]): Service exited due to SIGHUP | sent by killall[9566]
However, this does not result in an automatic restart of mDNSResponderHelper and I have to manually pkill mDNSResponder to get the Helper started again. Hopefully there is a better way to flush the DNS cache.