Genius Software Sequence Analysis

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Userfriendly, intuitive interface packed full of essential genomics tools for Sanger, NGS and long read sequence analysis, including pairwise and multiple alignments, de novo assembly, mapping, expression analysis, variant calling, NGS visualization, sequence and chromatogram analysis, automatic annotation, and phylogenetic tree building.

Perform a wide-range of cloning and primer design operations within one interface. Automatically annotate plasmid maps and expression vectors. Simulate a variety of molecular cloning operations including restriction cloning, Gibson Assembly, Gateway cloning and TOPO cloning. Design and test primers, find CRISPR sites, and optimize codons.

Simply drag and drop to import, export and convert your sequences, annotations and notes in common file formats including Genbank, SnapGene, FASTQ, FASTA, BAM, VCF, GFF, or import your complete Vector NTI database. Arrange and browse your data library how you like with document filtering, batch renaming, and document history automatically saved. Available for Mac, Windows and Linux.

Create your own automated workflows or use in-built workflows to increase efficiency, control business processes, and reduce human error in your research. Connect directly to databases including UniProt, NCBI (Entrez), BLAST and PubMed. Databases searches can be automated, allowing you to continuously receive the latest information on genomes, sequences, and protein structures.

Transform data management across teams, increase process efficiency and improve collaboration with intuitive folder-based organization and a seamlessly integrated shared database. Geneious Server Database is also available to purchase with a greater level of control and increased security for data access for your organization over the standard shared database.

Extend the functionality of Geneious Prime with our collection of plugins available for assembly, alignment, phylogenetics and more. Integrate with existing systems and add your own custom algorithms using a highly interoperable API.

Simply switch between industry leading algorithms for mapping and de novo assembly

Support for assembly of Sanger and NGS data, including Illumina, PacBio and Oxford Nanopore reads of any length, including paired-end reads and hybrid assemblies

Produce circular contigs when assembling microbial genomes, plasmids and other circular sequences

Genome comparison and finishing with MAUVE genome alignment

Mappers including Geneious, Geneious for RNA Seq, BBMap, Minimap2, Bowtie2 and TopHat

De novo assembly algorithms including Geneious, SPAdes, Flye, MIRA, Tadpole and Velvet

Multiple and pairwise sequence alignment of DNA or protein including full genome alignment

Align with trusted algorithms including Geneious Aligner, MUSCLE, MAFFT, Clustal Omega, MAUVE and LastZ

View and edit alignments with real-time translation and highlightingze using PCA and volcano plots

Automatically design PCR and sequencing primers and hybridization probes, to any target region or entire sequence

Easily add primers in the Sequence View

Design basic and degenerate PCR primers

Add and remove extensions to a primer sequence before, during or after the design process

Primer specificity testing to check for additional binding sites on the template sequence

Screen for physical properties, hairpins and primer-dimers

Drag and drop your primers in FASTA, spreadsheet or GenBank format

Create workflows for automated bulk analysis using a visual editor

More than 20 in-built workflows for performing

pipelines including Apply Variants to Reference Sequence, Map Reads then find SNPs, and Randomly Sample Sequences

Extend capabilities with option to write custom code workflows

Add specialized functionality or integrate with other systems using the Plugin Development Kit

Add your favorite algorithm, database or visualization

Wrap a command line program to run via the Geneious Prime GUI

A recent phishing attempt has targeted the Harvard community and appears to be sent from a legitimate Harvard email address. For more information and to learn how to safeguard your accounts, visit the phishing alert news article.

Geneious offers an intuitive and robust suite of molecular biology and sequence analysis tools, making it simpler and more efficient for researchers to manage and analyze DNA, RNA, and protein sequences. With this service, you can enhance the accuracy of your findings, streamline your research processes, and collaborate with peers effortlessly.

Eligibility for Geneious requires users to be on the HMS network, either directly or via the HMS VPN. Only members of HMS who are based on-quad can access this license. Additionally, users must only run Geneious when actively using it to ensure fair usage due to limited network licenses.

Geneious ensures a high level of security through its connectivity requirements. Access is only allowed from the HMS network, ensuring authorized members can use the service. This limited access enhances security and protects sensitive data from unauthorized users.

Accelerate research and make groundbreaking insights with advanced molecular biology tools in Geneious Biologics with your Dotmatics data. Geneious Biologics provides advanced analytics and intuitive visualizations for a wide range of antibody-like molecules, helping you to extract the maximum value from your datasets.

Drive data-driven insights by connecting relevant assay data to sequences in Geneious Biologics where entities can be annotated and analyzed in a single collaborative workspace. This also complements Dotmatics dashboards with detailed sequence analysis capabilities in Geneious Biologics so researchers can see all of the associated data in the context they need.

Data from antibody assays can be sent automatically to Geneious Biologics, streamlining the process of associating assay data with sequence data and accelerating candidate selection. This decreases both time spent collating assay data and the risks of introducing inadvertent errors, driving your team's efficiency and accuracy.

Improve data quality by replacing manual data transfers with programmatic exchange of data and sequence annotations calculated in Geneious Biologics and included in the registration records. Using the Geneious Biologics Integration, researchers can register a single or multiple antibody sequences into the Dotmatics biological registration system.

With access to Geneious Biologics capabilities, Dotmatics users save hours in the lab with industry leading algorithms, powerful analyses and superior annotations. Researchers can create high-quality libraries, select the optimal therapeutic candidates and share those insights with other researchers on the team.

When combined with the breadth and depth of collaborative capabilities in Dotmatics, Geneious Biologics enables powerful antibody sequence annotation and analysis, allowing your team to get the results they need, together.

BBC's "Sherlock" has been widely praised since it debut in 2010 thanks to it's razor sharp dialog, witty humor, and gorgeous production. From a filmmaking perspective there is much to be admired, which is why we were thrilled to see Nerdwriter1 use the Conan Doyle adaptation as his latest subject in his latest YouTube video essay.

For those not familiar with The Nerdwriter's YouTube channel, Evan Pushak examines artwork of all kinds in the form of a video essay. Subscriptions have recently topped one million, and for good reason. His well produced video essays are well informed and hugely watchable. So much so, that this isn't the first time we've featured one of his video essays.

In his latest video, The Nerdwriter tears apart a 3 minute, 42 second sequence in which Sherlock Holmes solves an important mystery from the latest episode. The use of editing and camera work is applauded for it's ability to add context to the story, and take the viewer through the main character's thought process. I enjoyed watching Nerdwriter's analysis of the intelligent sequence just as much as watching it unfold in the episode itself.

There are plenty of film analysis channels on YouTube, but I think the genius of The Nerdwriter is in his ability to use beautiful visuals and infographics, within a storytelling construct of it's own. Much can be learned of filmmaking from the content of his channel. But his ability to engage an audience for over seven minutes when analyzing a scene that is less than four minutes long is an education in YouTube filmmaking itself.

Mike Briggs is the Co-founder & Creative Director of Ranch Creative, a UK based content-creation agency. Mike has created content across many genres of industry & commerce including global sports brands, fashion houses & tech companies.

Unfortunately, this new series of Sherlock (series 4) has been slated by much of the UK media. Only yesterday, one headline ran: It's the crime of the century! How they turned once magical Sherlock into self-indulgent twaddle.

In general, the scriptwriters Gatiss and Moffat have been accused of trying to be too smartar*e, Cumberbatch, too arrogant and Freeman, 'an a**ehole'! I must admit, it's curious viewing, and not difficult to see why the media has come down against it. Shame, because it was one of the most watchable shows on the box.

This study by Sokač et al. entitled "GENIUS: GEnome traNsformatIon and spatial representation of mUltiomicS data" presents an integrative multi-omics approach which maps several genomic data sources onto an image structure on which established deep-learning methods are trained with the purpose of classifying samples by their metastatic disease progression signatures. Using published samples from the Cancer Genome Atlas the authors characterize the classification performance of their method which only seems to yield results when mapped onto one out of four tested image-layouts.

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