Whenactinomycin D was used as an immunodepressant in a dose of 2.5 mg/kg, interferon formation was reduced by 16 times compared with the control and antibody production was completely suppressed. Hydrocortisone, in a dose of 100 mg/kg body weight, also reduced interferon production by 16 times, but antibody formation against Newcastle disease virus was undisturbed. Hydrocortisone affects the formation of antiviral immunity in a similar way to antilymphocytic serum, whereas the action of actinomycin D can be compared with that of x-ray irradiation and imuran, suggesting heterogeneity of the population of interferon-producing cells in the body.
Hi, all. I will likely be starting imuran very soon (if my bloodwork comes back good) and while side effects lists are readily available, I was curious if anyone would be willing to share their stories with how imuran went for them.
I was put on Imuran but broke out in a rash all over my body with intense itching that kept me awake at night.
Discontinued Imuran started to clear up rash and put on Cellcept
with the same side effects. So I cannot tolerate either of these drugs.
I was on Imuran 150mg per day for about three years. It worked well for me, reducing my MG symptoms considerably, with no noticeable side effects. Then my blood results began to show abnormalities resembling those of leukemia. After a big scare, the blood symptoms were definitively linked to the Imuran. I had to stop immediately, and my blood returned to normal after a few months. My neurologist and I have battled to find a workable alternative and will try cellcept shortly.
I was on Imuran for about 2 years. Initially, I did fine and it helped. But my MG progressed and I developed a tolerance so my neurologist increased my dosage. My blood work showed severe decreased RBC and ultimately I developed severe anemia. I can no longer take it. All immunosuppressants now cause anemia.
My suggestion if you start the drug: get weekly blood tests in the early days. My neurologist told me I could wait a month before getting a test. In retrospect, I should have listened to my body and had my blood checked earlier.
High blood pressure, High blood glucose, Extreme weight gain, water retention, and the best one, my liver doubled in size. Yes the doctors should have kept up with my liver enzymes. They did not. They did not do anything except for 3 month checkups. I went through 4 neurologists before 1 referred me to Major Teaching Hospital.
I have GMG, diagnosed 10/2018; I take 100/mg day Imuran, 240/mg day Mestonin and 5/mg day prednisone. I also yet yearly Rituxin infusions. I have muscle weakness and pain in joints. I also notice slight hair loss but it always grows back in.
I have GMG, age 76 diagnosed at 64. Imuran made me intolerably sick in about 10 days. I actually checked myself into the hospital thinking I was having a heart attack, my arrhythmia was so intense. Nope, just the Imuran. Quit that and within 24 hours just fine. Cellcept now for five years without any side effects. Down to .5 mg prednisone plus 240mg mestinon and semimonthly Soliris. Doing very well.
I was given Azathioprine after a period of time on 20mg of prednisone and 60mg/day of mestinon. My dosing increased every two weeks and after 5or 6 weeks I went to the ER with a fever of 105.9. I was in for three days and had every culture, blood tests, scans and tests available. They found no infection and determined it was the Azathioprine. I have been on 2000mg of Cellcept since then. I am late onset as well (age 65 three years ago)
Hope you are doing well now John. Different people have different kinds of responses to almost every drug that we in the MG community. I have no negative response to my 200mg a day of azathioprine. Good luck!!!
I have taken Imuran for almost 2 years. I was on Humira for several years for RA and then developed MG so I was pulled. I take Imuran and have finally got down to 5 mg of prednisone for my MG and have not had any side effects from it. Good luck
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