Diagnostics for non-linear mixed-effects (population) models from 'NONMEM' . 'xpose' facilitates data import, creation of numerical run summary and provide 'ggplot2'-based graphics for data exploration and model diagnostics.
XPose! includes the unique Continuous Calibration Technology (CCT). During the exposure, the performance of every laser diode in any wavelength is monitored and automatically adjusted if necessary. Costly inappropriate exposures can thus be eliminated.
The fleXtreme! optic is an in-house development by Lscher and allows the selection of any desired resolution. The changeover is fully automatic and tailored to requirements. This means that every job could be exposed in any resolution.
The broad band optical system by Lscher allows any combination of wo different types of laser diodes in one machine. Switching between the two laser sources is done by a simple click of a button. Every wavelength can be configured individually, if just one source is needed at the time. Possible combinations are:
With this combination, any UV sensitive material and any ablative plate can be imaged easily, quickly and safely. This applies to conventional offset plates, rotary screens, such as Screeny by Gallus, TecScreen by Kocher + Beck or RotaPlate by spg, as well as to letter press and flexo plates.
With this combination, any UV sensitive material and any thermal offset printing plate can be processed quickly and in highest quality in one machine. This applies to conventional offset plates, rotary screens, such as Screeny by Gallus, TecScreen by Kocher + Beck or RotaPlate by spg as well as to any conventional thermal offset plate.
Certara.Xpose.NLME is an R package used to creates xpose databases (xpose_data) for PML/NLME results. Additionally, Certara.Xpose.NLME offers various covariate model diagnostic functions, not available in the xpose package.
This Function is used to create a VPC in xpose using the output from the vpc command in Pearl Speaks NONMEM (PsN). The function reads in the output files created by PsN and creates a plot from the data. The dependent variable, independent variable and conditioning variable are automatically determined from the PsN files.
vpctabThe vpctab from the vpc command in PsN. For example vpctab5, or if the file is in a separate directory ./vpc_dir1/vpctab5. Can be NULL. The default looks in the current working directory and takes the first file that starts with vpctab that it finds. Note that this default can result in the wrong files being read if there are multiple vpctab files in the directory. One of object or vpctab is required. If both are present then the information from the vpctab will over-ride the xpose data object object (i.e. the values from the vpctab will replace any matching values in the object\@Data portion of the xposedata object).
objectAn xpose data object. Created from xpose.data. One of object or vpctab is required. If both are present then the information from the vpctab will over-ride the xpose data object object (i.e. the values from the vpctab will replace any matching values in the object\@Data portion of the xpose data object).
byA string or a vector of strings with the name(s) of the conditioning variables. For example by = c("SEX","WT"). Because thefunction automatically determines the conditioning variable from the PsN input file specified in vpc.info, the by command can control if separate plots are created for each condition (by=NULL), or if a conditioning plot should be created (by="WT" for example). If the vpc.info file has a conditioning variable then by must match that variable. If there is no conditioning variable in vpc.info then the PI for each conditioned plot will be the PI for the entire data set (not only for the conditioning subset).
PI.ciPlot the confidence interval for the simulated data'spercentiles for each bin (for each simulated data set compute thepercentiles for each bin, then, from all of the percentiles from all of thesimulated datasets compute the 95% CI of these percentiles). Values can be"both", "area" or "lines". These CIs can be used toasses the PI.real values for model misspecification. Note that withfew observations per bin the CIs will be approximate because the percentiles in each bin will be approximate. For example, the 95th percentile of 4 data points will always be the largest of the 4 data points.
PI.ci.area.smoothShould the "area" for PI.ci be smoothed tomatch the "lines" argument? Allowed values are TRUE/FALSE. The "area"is set by default to show the bins used in the PI.ci computation. Bysmoothing, information is lost and, in general, the confidence intervalswill be smaller than they are in reality.
PI.realPlot the percentiles of the real data in the various bins. values can be NULL or TRUE. Note that for a bin with few actual observations the percentiles will be approximate. For example, the 95th percentile of 4 data points will always be the largest of the 4 data points.
Plot the percentiles of one simulated data set in each bin. TRUE takes the first mirror from vpc_results.csv and AN.INTEGER.VALUE can be 1, 2, ... n where n is the number of mirror's output in the vpc_results.csv file.
A vector of two values that describe the limits of the prediction interval that should be displayed. These limits should be found in the vpc_results.csv file. These limits are also used as the percentages for the PI.real, PI.mirror and PI.ci. However, the confidence interval in PI.ci is always the one defined in the vpc_results.csv file.
Should the "area" for PI.ci be smoothed to match the "lines" argument? Allowed values are TRUE/FALSE. The "area" is set by default to show the bins used in the PI.ci computation. By smoothing, information is lost and, in general, the confidence intervals will be smaller than they are in reality.
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