Atomic Template Ski Binding
Sacha Weakland
Few words to start with. I am not an authorized Atomic installer, nor do I have any real experience dealing with bindings, I just happened to be VERY familiar with Atomic bindings, as they are VERY easy to install. Just to guide anyone along that has wanted to do it, but it's pretty self explainitory, just don't blame me for anything.
Take the rear binding assembly (plate + post) and place it over the mounting holes (the middle ones apply to most people). Gently screw in the two screws shown so the binding band comes loose, and then remove the rear post, so you can torque down the four screws holding the rear plate in place.
The front mounting plate with the three mounting screws shown. Place the plate onto the mounting holes, again, for most people, the center holes (on my skis, they have the brass inserts) will be sufficient. Screw the plate into place.
Keeping the red tab as far to the right as possible, slide the front binding post onto the track of the front plate, sliding the post on from the front of the ski, and sliding it back toward the rear post. When I mounted mine, I locked it into the "Speed" setting.
Not shown, but place the rear binding band on TOP of the front binding band, and line up the holes that correspond to your boot size. I find the numbers hard to read, so just do a fit and check I used the third hole in for my 325mm sole length. Once the holes are lined up, slide the top plate from the back of the ski, into the front post, and it should fall right into place. Tighten the screw to hold the two bands together (this is the heart of the freeflex system, which allows the rear post to float freely in the track).
This is the binding adjustment screw. Because the holes in the bands only adjust every 10mm (320mm, 330mm, etc) this screw provides any size inbetween (323mm, 325mm, etc). Tighten/loosen this screw until it is FLUSH with the back of the binding. When you run your finger over the screw, it should feel even with the back surface of the binding.
I'm thinking of moving the front post up to the front screws (as I currently have it setup on my GS:9s) therefore keeping the whole rear binding post in the track, but if yours hangs out, then I might as well keep it the way it is.
I agree I love Markers, but my Atomics can only take Atomics so thats what I'm stuck with. The only thing I like about the Atomics is the varizone settings. Other than that I think they are heavy and cumbersome to lockup.
Well I had to go back and reinstallt he front posts once or twice, till I decided where I wanted them....and even now, I think I'm going to move them forward...but I'd say 20 minutes? If I knew the exact way I wanted them, I could easilly do it in 10...all it is is screw screws into predrilled holes.
Jeff, where are you going to take your bindings to get the release check and din setting done? Nestors isn't an authorized dealer, I called to ask for the heck of it how much it costs to do the mounting. He said they are not an authorized atomic dealer and are not sure if they can mount/check atomic bindings. He told me to check either Pelican or the Loft.
The parent div has aria-live=polite so that screen readers know the child elements will update their content. The div has multiple children that all update their content based on the value of different variables. I want to ensure the indicated child div (the first one) is read through screen reader when it updates, and not the others. My question is what value of aria-relevant should be used in the child div? Acccording to the documentation, the options are additions,removals,text. It is my understanding that additions implies elements underneath the parent are added to the DOM, removal means elements are removed from the DOM and text means the text is removed or added,
I am unsure what exactly goes on under the hood when Angular binds to the template with . Does it actually remove the child element from the DOM and replace it with another? Or does it update the content of the child element? From the perspective of the screen reader, is there any difference between the two operations?
Child elements that should not be announced really shouldn't be children of the live region. There isn't a "none" value for aria-relevant. I suppose if you used "removals" and then never removed any DOM elements from the child and only updated the text of the child, then nothing would be announced.
For child elements that should announce something, I have never tried setting aria-relevant or aria-atomic on the child element. I always have the element with aria-live also have aria-relevant or aria-atomic.
For ligand binding prediction, it is crucial for molecular docking programs to integrate template-based modeling with a precise scoring function. Here, we proposed the CoDock-Ligand docking method that combines template-based modeling and the GNINA scoring function, a Convolutional Neural Network-based scoring function, for the ligand binding prediction in CASP15. Among the 21 targets, we obtained successful predictions in top 5 submissions for 14 targets and partially successful predictions for 4 targets. In particular, for the most complicated target, H1114, which contains 56 metal cofactors and small molecules, our docking method successfully predicted the binding of most ligands. Analysis of the failed systems showed that the predicted receptor protein presented conformational changes in the backbone and side chains of the binding site residues, which may cause large structural deviations in the ligand binding prediction. In summary, our hybrid docking scheme was efficiently adapted to the ligand binding prediction challenges in CASP15.
Several computational methods have been developed for ligand binding prediction. Well-known ligand prediction programs include DOCK [4], AutoDock [5], Vina [6], Glide [7], GOLD [8], and MDock [9]. Recently, template-based methods have been widely used to predict ligand structures. Huang et al. proposed an enhanced Virtual Screening (VS) approach, EViS [10], which integrates ligand docking, protein pocket template searching, and ligand template shape similarity calculations. Zou et al. [11] proposed a new template-guided method using dissimilar ligands as templates, which significantly outperformed traditional molecular docking methods. PocketShape [12] used the Hungarian algorithm and the Downhill simplex method to solve the problem of binding site comparison, and achieved excellent performance in distinguishing similar from dissimilar ligand binding site pairs. To enrich the AlphaFold model with ligands and cofactors, AlphaFill [13] uses sequence and structural similarities to align small molecules and ions from experimentally determined structures with AF2 predicted protein models.
In addition, convolutional neural networks (CNNs) have been used in structure-based virtual screening and scoring. Ragoza et al. [14] showed that a fully CNN scoring function (GNINA scoring function) using only spatial and atom type information as input can outperform empirical and feature-based machine learning approaches for virtual screening. Deane et al. [15] used a Densely connected CNN (DenseNet) with a transfer learning approach to produce an ensemble of protein family-specific models for virtual screening. Jones et al. [16] fused models of 3D-CNNs and spatial graph neural networks (SG-CNNs) to make more accurate predictions than the previous docking scoring and MM/GBSA rescoring.
In CASP15, we participated in the category of ligand binding prediction. Owing to the advantages of template-based modeling and the GNINA scoring function, we combined these two methods to predict the binding modes of small molecules or metal ions. For most of the CASP15 ligand systems, our fusion docking protocol achieved successful or partially successful results. Considering its robust predictive performance, our docking protocol is a good alternative for the ligand binding predictions.
Flow chart of the CoDock-Ligand protocol. First, the receptor pocket templates are searched in the template library using the pocket 3D alignment algorithm. Second, multiple ligand conformations are generated using RDKit. Finally, the ligand conformations are aligned to the small molecules from the pocket template, and the variety binding poses are sorted by the GNINA scoring function
Ligand prediction of H1114. The receptor protein and ligands of the crystal structure are colored light blue and orange, respectively. The predicted ligand structures are colored pink. A Ligands of Ni ion, FCO, and Mg ion. B Ligands of F3S and MQ7
Analysis the effect of the side chain on ligand prediction. The crystal structures of receptor protein and ligand are colored light blue and orange, respectively. The predicted structures of receptor protein and ligand are colored light green and pink, respectively. A Prediction of MQ7 in H1114. The side chain of TYR275 leads to the incorrect conformation of MQ7. B Prediction of DW0 in T1188. The side chain of TRP120 leads to the orientation change of the aromatic ring in DW0
For some target systems, complex templates with high similarity scores were identified, including H1114, R1117, T1124, T1127, H1135, T1146, T1152, T1158, T1170, H1171, H1172 and T1186. For ligands identical to those in the complex template, structure-based alignment was directly used to obtain the ligand position in the predicted target. For example, the ligand of R1117 and metal ions of H1114 were predicted in this manner. For the ion ligands, a simple coordinate transformation was used for docking prediction. For ligands chemically similar to those in the complex templates, template guided docking protocol was used to obtain the target-ligand complex structure. It was applied for the ligand predictions of T1124, T1158 v1, T1158 v2, and T1152. For target systems without appropriate complex templates, such as T1181 and T1187, traditional docking was performed using Glide [7]. Previous study compared Glide and GNINA on the CASF-2016 dataset [25], and demonstrated that Glide performed slightly better than GNINA. When no acceptable template structures were found, Glide was used for docking.
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