TopFD MS3 deconvolution?

[wingk...@gmail.com]

Hi Dr. Liu,

This is Preston from The Chinese University of Hong Kong.

I am currently having a project to perform MS3 analysis on intact histones and I can see some promising fragments in the MS3 spectra.

I would like to see if it is possible to use TopFD to deconvolute the MS3 spectra. Currently I am just manually inspecting the spectra. It would be nice to get a .msalign file with deconvoluted mass to work on.

The idea I could think of now is maybe change the ms3 header in the mzml file to ms2 to fool TopFD.

Best,

Preston

[Liu, Xiaowen (Kevin)]

Hi, Preston,

 

If you can share with us an MS3 data, ,we will check if we can add a function to TopFD for MS3 spectral deconvolution.

 

Best,

 

Xiaowen (Kevin)

 

From: top-dow...@googlegroups.com <top-dow...@googlegroups.com> on behalf of wingk...@gmail.com <wingk...@gmail.com>
Date: Tuesday, February 18, 2025 at 4:16 AM
To: TopPIC <top-dow...@googlegroups.com>
Subject: [ms-align-plus-pipeline] TopFD MS3 deconvolution?

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