MedCalcis available in different versions for 32-bits and 64-bits Windows editions. The 32-bits version will work on both Windows editions. The 64-bits version will work on 64-bits Windows editions only. But if you are experiencing problems with the 64-bits version, you should use the 32-bits version (both have the same functionality).
With the free MedCalc file viewer you can open MedCalc files (*.mc1) without the need for a MedCalc license. This file viewer has limited capabilities and will not allow to perform new statistical analyses or create new graphs.
Mercaldo ND, Lau KF, Zhou XH (2007) Confidence intervals for predictive values with an emphasis to case-control studies. Statistics in Medicine 26:2170-2183. Updated translations and language files. Version 16.8 - August 4, 2016 In Plot versus criterion values (ROC curve analysis): Added plot against Efficiency (Greiner et al., 2000). Added option "Observed prevalence". Added Positive and Negative predictive value, and Youden index. Report of maximum or minimum of some statistics in the graph's info box. Added Spearman's rank correlation coefficient in the output of Passing & Bablok regression. Version 16.4 - April 11, 2016 New: Comparison of multiple methods. Plot versus criterion values (ROC curve analysis): added plot of Cost and Misclassification-Cost Term (MCT, Greiner et al., 2000) against criterion values. Meta-analysis: both fixed effect model weights and random effect model weights are now reported. Meta-analysis: for marker size relative to study weight you can choose the fixed effect model weights or random effect model weights. Meta-analysis: the presentation of the pooled effect under the fixed effects or random models is now optional in the forest plot. Meta-analysis: when a diamond representation for the pooled effects is used then a different marker color for the pooled effect can be selected. Increased the maximum number of files in the recent file list to 20 (you can set the preferred number in the MedCalc options panel. Version 16.2 - February 4, 2016 Added Weight (%) in the output of the different meta-analysis procedures. Fixed some problems when working with a dual monitor setup. Changed the algorithm that enables some menu items in the Edit menu. In particular, the Del command is now enabled for items in the Contents window (Saved tests and graphs). Version 16.1 - January 6, 2016 Added the possibility to perform different independent samples and paired samples t-tests, Mann-Whitney tests and Wilcoxon tests in one single procedure, see Comparison of independent samples and Comparison of paired samples. Added the possibility to save (or append) results, graphs and spreadsheet data to Word documents (docx). Use the new button or the Ctrl+W keyboard shortcut. Ctrl+W also works in the dialogs for sample size calculation and the dialogs in the Tests menu. This feature requires Microsoft .NET 4 framework, which is already available on most Windows PCs, or can be downloaded freely from the Microsoft website. Added importing and saving as OpenOffice or LibreOffice's Calc spreadsheet files (*.ods). Current version reads/writes data only and ignores formatting. Added "Save as web page (*.html)" for spreadsheet data. Added 99.9% and 99.99% reference intervals. Added confidence intervals for indices of responsiveness. Change in the algorithm of the Trimmed mean and its 95% CI. See Calculation of Trimmed Mean, SE and confidence interval for computational details. Added new spreadsheet functions: TrimMean(k,range), TrimMeanSEM(k,range), TrimMeanLow(k,ci,range) and TrimMeanHigh(k,ci,range): see Trimmed mean functions VTrimMean(k,variable[,filter]), VTrimMeanSEM(k,variable[,filter]), VTrimMeanLow(k,ci,variable[,filter]) and VTrimMeanHigh(k,ci,variable[,filter]): see Trimmed mean functions on variables Median(range) Median function Percentile(p,range) Percentile function Version 15.11 - November 27, 2015 Improved formatting of Box-and-whisker plots in Clustered Multiple Comparison graphs and Clustered Multiple Variables graphs. Improved auto-update. Chi-squared test: the use of Yates' correction for continuity is no longer recommended. For a 2x2 table, MedCalc version 15.11 uses the "N-1" Chi-squared test as recommended by Campbell (2007) and Richardson (2011). This is also applicable in Comparison of proportions. For the McNemar test (comparison of paired proportions) P-values are now always based on the cumulative binomial distribution. Version 15.10 - October 22, 2015 Added Probit regression (Dose-Response analysis). Improved stable algorithm for sorting spreadsheet data. Some minor Windows 10 compatibility fixes. Version 15.8 - August 14, 2015 Added a Funnel plot in meta-analysis. Added a Generic inverse variance method for meta-analysis. Improved Draw ellipse tool: press the shift key to draw a circle. Some speed improvements. Version 15.6 - June 2, 2015 New Format graph options: Side margins: this option lets you set a margin between the chart's boundary and lines for the X and Y axis. Allow exponential notation: when this option is selected, the program will display small or high numbers in exponential notation. New option in Kruskal-Wallis test: Jonckheere-Terpstra trend test. New spreadsheet functions: ANY(test,value[,value,...]) returns 1 or TRUE if the value of test matches any of the subsequent values; returns 0 or FALSE otherwise PROPER(str) sets the first character in each word to uppercase and the rest to lowercase E() returns Euler's constant 2.718281828459... BinomialLow(successes,trials,ival) returns the lower bound of the ival% Confidence Interval of the Binomial probability of a number of successes in a number of trials BinomialHigh(successes,trials,ival) returns the upper bound of the ival% Confidence Interval of the Binomial probability of a number of successes in a number of trials Revised spreadsheet functions: ROW(cell) returns the row number of a spreadsheet cell COLUMN(cell) returns the column number of a spreadsheet cell Additions in Logistic regression: Wald statistic, Cox & Snell R2 and Nagelkerke R2. Version 15.4 - April 20, 2015 Added a Correlogram as an option in Correlation table. Significant results with P
Sheskin DJ (2004) Handbook of parametric and nonparametric statistical procedures. 3rd ed. Boca Raton: Chapman & Hall /CRC. Sheskin DJ (2011) Handbook of parametric and nonparametric statistical procedures. 5th ed. Boca Raton: Chapman & Hall /CRC. Added a context menu item for the Multiple ROC plot to mark the point corresponding with the highest Youden index. Added an option to draw the Line of equality in a Scatter diagram. Version 12 - October 1, 2011 This update is available in different versions for 32-bits and 64-bits Windows editions. How to determine whether a computer is running a 32-bit version or 64-bit version of the Windows operating system (link to Microsoft website). MedCalc 12 does not work on Windows 2000 or prior versions of Windows. Windows 2000 reached the end of its lifecycle on 13 July 2010. It does no longer receive new security updates and new security-related hotfixes. Therefore it is strongly advised to switch to a newer version of Windows. File compatibility: this new MedCalc version can open and read MedCalc files created by any older version of the software. Files created with this new version (new files or saved files) cannot be read by older versions of the software. Improved support for Asian languages. List variables alphabetically (see Options): when this option is selected, variables are listed alphabetically in the selector boxes for variables. When this option is not selected, the variables are listed in the order they are entered in the spreadsheet. This option does not influence the order of the variables in the spreadsheet. Auto-complete function in selectors for variables and selection criteria (see Options). When you select a variable or selection criterion you can press function key F8 to call the formula editor for variables or selection criteria. Added the possibility to assign labels to data values. These labels are used for subgroup identification in graphs. Columns can be formatted specifically to contain date and time data. See Format spreadsheet (Column tab), How to enter dates. Changes in Passing & Bablok regression: Exact P-value for the cusum linearity test. Added option to calculate perpendicular residuals (see Passing & Bablok, 1983). Added an option to plot the residuals by rank order (see Passing & Bablok, 1983). Added Number Needed to Treat (NTT) with its 95% CI to the results of Relative risk. Added option to save prognostic indices in Cox proportional hazard regression. Added the Hosmer & Lemeshow test in Logistic regression. Added an option to plot a moving average in Multiple line graph. Save graph as a PowerPoint slide (see Export graphs). New ISEMPTY() function. See Logical functions. Change of the method for the calculation of the Standard Error (SE) of the Area Under the ROC Curve according to Hanley & McNeil (1982). Hanley & McNeil give 2 methods for the calculation of the SE, one in table II (p. 31) and one using equation 2 on page 33. The latter was used in previous versions of MedCalc. Added the calculation of exact binomial confidence intervals for positive and negative predictive value in the Predictive values calculator, if sample size is known.
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