The original definition of RF was for fully dichotomic trees, but it's easy to generalise for trees with polytomies. I think Penny & Hendy were the first to do this. The resulting generalised measure is still meaningful, but it takes into account time topological disagreement *and* differences in the degree resolution of the trees. You may want to quantify topological disagreement and resolution separately; quartet-based measures are good for that.
It may be better to call this quantity a "bipartition difference" instead of RF, to be strict with the definitions.