[Getdata Graph Digitizer 2.26 Key

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Getdata Graph Digitizer 2.26 Key


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Background: This meta-analysis of randomized controlled trials (RCTs) was aimed at comparing coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI) for the treatment of unprotected left main coronary disease.

Methods: All RCTs randomizing patients to any type of PCI with stents vs. CABG for left main disease (LMD) were included. Primary outcome was a composite of follow-up death/myocardial infarction/stroke/repeat revascularization. Secondary outcomes were peri-procedural mortality and the individual components of the primary outcome. Incidence rate ratio (IRR) or odds ratio (OR) and 95% confidence intervals (CIs) were pooled using a generic inverse variance method with random effects model. Subgroup analyses were done based on: (I) type of PCI [bare metal stents (BMS) vs. drug-eluting stents (DES)] and; (II) mean SYNTAX score tertiles. Leave one-out analysis and meta-regression were performed.

Traditionally, left main disease (LMD) has been considered an indication for surgery (1). However, last year the publications of the NOBLE and EXCEL trials, which respectively denied and supported the non-inferiority of percutaneous coronary intervention (PCI) compared to coronary artery bypass grafting (CABG) for LMD, have fueled the debate, adding uncertainty with respect to what the optimal strategy of revascularization for the treatment for patients with unprotected LMD should be.

Herein we perform a meta-analysis of the randomized trials that compare the two treatment options. We also evaluate the effect of the evolution in stent types and SYNTAX (SYNergy between PCI with TAXUS and Cardiac Surgery) score on outcomes.

This meta-analysis was performed in accordance with the Meta-Analysis of Observational Studies in Epidemiology (MOOSE) guidelines (Table S1) and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (2,3).

Investigators examined references at the title/abstract level, with divergences resolved by consensus, and then, if any potentially pertinent title/abstract was found, the complete article was retrieved. All articles with random allocation to treatment, comparing CABG to PCI with stents for unprotected LMD, were included.

The primary outcome was a composite of follow-up death/myocardial infarction/stroke/repeat revascularization at the longest available follow-up. The secondary outcomes were peri-procedural mortality, and the individual components of the primary outcome.

For the primary outcome, two different subgroup analyses were conducted based on: (I) type of stents used in the PCI group [bare metal stents (BMS) vs. drug-eluting stents (DES)]; and (II) tertiles of mean SYNTAX score. The cut-offs for 1st and 2nd tertiles were 22.80 and 25.05, respectively.

Relative effect estimates were calculated as log incidence rate ratios (IRRs) or odds ratio (OR) with 95% confidence intervals (95% CIs). We pooled late outcomes as natural logarithm of the IRR to account for potentially different follow-up durations between different treatments. We estimated the IRR through different means depending on the available study data. When hazard ratios (HRs) were reported, we took the natural logarithm of the HR with standard error (SE) calculated from the 95% CI or log rank P value (7). When Kaplan Meier (K-M) curves were present, event rates were estimated from the curves using GetData Graph Digitizer software 2.26 ( -graph-digitizer.com/) and in case of absence of K-M curves, we used the reported event rates to calculate the IRR, as previously described (8,9).

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