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The Configurable Pipeline for the Analysis of Connectomes (C-PAC) is an open-source software pipeline for automated preprocessing and analysis of resting-state fMRI data. C-PAC builds upon a robust set of existing software packages including AFNI, FSL, and ANTS, and makes it easy for both novice users and experts to explore their data using a wide array of analytic tools. Users define analysis pipelines by specifying a combination of preprocessing options and analyses to be run on an arbitrary number of subjects. Results can then be compared across groups using the integrated group statistics feature.
Researchers can now explore functional connectome data from thousands of subjects made public through releases by the International Neuroimaging Data-Sharing Initiative (INDI) and 1000 Functional Connectomes Project. With this in mind, C-PAC has been designed to reliably preprocess and analyize data for hundreds of subjects in a single run, either on a single machine or on a compute cluster using Sun Grid Engine, HTCondor, or Portable Batch System.
Different analysis pipelines can produce significantly different results, raising questions about the replicability and reliability of brain imaging findings. C-PAC makes it easy to explore the impact of particular processing decisions by allowing users to run a factorial number of analysis pipelines, each with a different set of preprocessing and analysis options. An integrated Quality Control interface facillitates rapid manual examination of pipeline outputs and selection of subjects to be included in group comparisons.
Under the terms of the merger agreement, CPAC shareholders will receive $8.65 in cash for each share of CPAC common stock they hold, representing a 16% premium over the average closing price of CPAC's common stock over the last 90 trading days.
CPAC's Chairman of the Board and Chief Executive Officer, Thomas N. Hendrickson said, "After careful analysis, our Board of Directors has unanimously endorsed this transaction as being in the best interest of our shareholders. We believe that Buckingham's all cash offer represents an attractive premium to our current trading price. After a thorough and deliberate analysis of all of our alternatives, we recommend that our shareholders adopt the merger agreement."
Pending receipt of shareholder approval as well as satisfaction of other customary closing conditions, the transaction is expected to be completed in the first quarter of calendar year 2007. Debt financing for Buckingham Capital Partners has been committed by LaSalle Bank and Fifth Street Capital.
William Blair & Company, L.L.C. is acting as financial advisor to CPAC, Inc. KeyBanc Capital Markets, an independent investment advisor, provided a Fairness Opinion to CPAC's Board of Directors. Lincoln International L.L.C is acting as financial advisor to Buckingham Capital Partners. About CPAC, Inc.
Established in 1969, CPAC, Inc. (cpac.com) manages holdings in two industries. The Fuller Brands segment manufactures commercial, industrial, and household cleaning products, as well as custom brushes and personal care lines. The CPAC Imaging segment develops and markets innovative Imaging chemicals, equipment, and supplies at seven operations worldwide. Products are sold under more than 350 registered trademarks. Stock is traded under the symbol: CPAK.
In connection with the proposed merger and the special meeting of CPAC's shareholders to approve the proposed merger, CPAC, Inc. will file a proxy statement with the Securities and Exchange Commission. INVESTORS AND SECURITY HOLDERS ARE ADVISED TO READ THE PROXY STATEMENT WHEN IT BECOMES AVAILABLE, BECAUSE IT WILL CONTAIN IMPORTANT INFORMATION ABOUT THE MERGER AND THE PARTIES THERETO. Investors and security holders may obtain a free copy of the proxy statement (when available) and other documents filed by CPAC, Inc. at the Securities and Exchange Commission's web site at The proxy statement and such other documents may also be obtained for free from CPAC, Inc. by directing such request to CPAC, Inc., Investor Relations, PO Box 175, 2364 Leicester Road, Leicester, NY 14481. Telephone: (585) 382-2339.
CPAC, Inc. and its directors, executive officers and other members of its management and employees may be deemed to be participants in the solicitation of proxies from its stockholders in connection with the proposed merger. Information concerning the interests of these participants in the solicitation, which may be different than those of CPAC shareholders generally, is set forth in CPAC's proxy statements and Annual Reports on Form 10-K, previously filed with the Securities and Exchange Commission, and will be set forth in the proxy statement relating to the merger when it becomes available.
Except for the historical matters contained herein, statements in this press release are forward-looking and are made pursuant to the safe harbor provisions of the Securities Litigation Reform Act of 1995. Investors are cautioned that forward-looking statements involve risks and uncertainties that may affect CPAC's business and prospects, including economic, competitive, governmental, technological, and other factors discussed in CPAC's filings with the Securities and Exchange Commission.
The Preprocessed Connectomes Project (PCP) is pleased to announce the public release and open sharing of preprocessed neuroimaging data from the Autism Brain Imaging Data Exchange (ABIDE). A consortium of the International Neuroimaging Datasharing Initiative (INDI), ABIDE is a collaboration of 16 international imaging sites that have aggregated and are openly sharing neuroimaging data from 539 individuals suffering from ASD and 573 typical controls. These 1112 datasets are composed of structural and resting state functional MRI data along with an extensive array of phenotypic information.Data from ABIDE was preprocessed by five different teams using their preferred tools. Functional preprocessing was performed using:the Connectome Computation System (CCS),the Configurable Pipeline for the Analysis of Connectomes (CPAC),the Data Processing Assistant for Resting-State fMRI (DPARSF) andthe NeuroImaging Analysis Kit. Due to the controversies surrounding bandpass filtering and global signal regression, four different preprocessing strategies were performed with each pipeline: all combinations of with and without filtering and with and without global signal correction. To limit the variance between outputs to just preprocessing, statistical derivatives for each pipeline and strategy were calculated by the CPAC software. Structural preprocessing and calculation of cortical measures was performed using three different pipelines:ANTS,CIVET,and FreeSurfer. Refer to the links at the top for more information about the different pipelines and derivatives.
Cameron Craddock, Yassine Benhajali, Carlton Chu, Francois Chouinard, Alan Evans, Andrs Jakab, Budhachandra Singh Khundrakpam, John David Lewis, Qingyang Li, Michael Milham, Chaogan Yan, Pierre Bellec (2013). The Neuro Bureau Preprocessing Initiative: open sharing of preprocessed neuroimaging data and derivatives. In Neuroinformatics 2013, Stockholm, Sweden.
1Center for the Developing Brain, Child Mind Institute, New York, New York, United States of America, 2Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, United States of America, 3Centre de recherche de l'institut de griatrie de Montral, Montral, Qubec, Canada, 4Dpartement d'informatique et de rechercheoprationnelle, Universit de Montral, Montral, Qubec, Canada, 5Department of Psychology, Yale University, New Haven, CT, United States of America, 6 Dpartement d'anthropologie,Universit de Montral, Montral, Qubec, Canada, 7Laboratory for Functional Connectome and Development, China Key Laboratory of Behavioral Science, Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China, 8The McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montral, Qubec, Canada, 9Phyllis Green and Randolph Co̅wen Institute for Pediatric Neuroscience at the NYU Child Study Center, New York University Langone Medical Center, New York, New York, United States of America
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Introduction: Recent legislation changes regarding cannabis in the United States highlights the importance of investigating the impact of regular cannabis use on populations, such as emerging adults, that will likely drive the market given their greater daily use (see Johnston et al., 2014). The endocannbinoid system plays a role in neurodevelopment (see Bossong & Niesink, 2010) and has been implicated in behavioral and emotional processing (see Moreira & Lutz, 2008; see Solinas et al., 2008; see Covey et al., 2014). The current study utilized a multisite functional magnetic resonance imaging (fMRI) dataset of intrinsic (a.k.a. no task/resting state) frontolimbic connectivity among healthy emerging adults. A secondary aim examined the relationship between cannabis group connectivity differences and self-reported mood and affect symptoms.
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