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How pathogenic microbes have been an intimate part of human history from the beginning--and how our deadliest germs and biggest pandemics are the product of our success as a speciesPlagues upon the Earth is a monumental history of humans and their germs. Weaving together a grand narrative of global history with insights from cutting-edge genetics, Kyle Harper explains why humanity's uniquely dangerous disease pool is rooted deep in our evolutionary past, and why its growth is accelerated by technological progress. He shows that the story of disease is entangled with the history of slavery, colonialism, and capitalism, and reveals the enduring effects of historical plagues all around us, in patterns of wealth, health, power, and inequality. He also tells the story of humanity's escape from infectious disease--a triumph that makes life as we know it possible, yet destabilizes the environment and fosters new diseases.Panoramic in scope, Plagues upon the Earth traces role of disease in