For my notes I use namespaces, for most RPG locations that I have had notes on this worked well because you can do things like 'Obelisk of Obliteration/Room 1'and 'Pinnacle of Mild Peril/Room 1' for the titles. Then use tags or other fields to let you organise things.
As a side note, templates are very useful for things like this.
You make a template that displays the room information in a way that is useful and then make each room tiddler just contain the required information in its fields. Someone on the forums here made/is making a wiki with all of the free DnD 5 content in it. Last I saw it was very well done and may be a good place to look for inspiration or for things to reuse.
And as an even more off-topic side note, I made Bob to get around the desire to put everything into one wiki, it lets you create a lot of wikis and can have an easy list of all of them in your wikis.
I changed from having one wiki with all the rpg info in it to one per module/scenario.