DOWN: There is no direct support for Android/mobile version (though you can maintain wikis in DT that can then be uploaded and they will be fine Android-ed).
UP: The KEY thing is that TiddlyDesktop, when you understand it, is NOT a one-way-ticket. (Essentially it is a chrome shell with built in saving and backup and more flex than a normal browser).
FWIW: I use it with single-file wikis I can ALSO edit in FF (but not simultaneous).
The issue is really one of those "man, it can get complicated!" understanding the FLEX of TW :-)
TT