Eric,
If you want an epic trip, head down to the South Holston on the SW border of VA/TN. Look it up on the Orvis reports page (the TN page has the tailrace report). I've been twice and it is really special. They've got dry fly fishing 350 days/year. Unfortunately its like 6 hours away at least. If you have the time and the inclination though, don't let the distance deter you as it is a sure fire bet.
For some stuff thats closer, some ideas are the spring creeks up in the Cumberland valley of south-central PA. Yellow Breeches is the lowest common denominator stream, and there is good fishing in there for mostly stocked fish (and wild browns if you know where to go). You could also check out Big Spring or the Letort. Streamer fishing is pretty good in those streams this time of year, but they are advanced level fisheries. In any case, lots of options up there.
Personally, I will be out in western Maryland. We're going to ski at Wisp on sunday (that's all the day will be good for, looking at the weather - 24 degrees and snow flurries is pretty chilly!). Monday though, I am going to fish in the morning on the Youghiogheny tailrace. If anybody has any experience with this fishery, I would really appreciate your thoughts!
Good luck Eric!
Misha