With the coming spring, I've begun assembling and tying flies for two of our local waterways. I searched the forum for effective fly patterns in 4MR and Holmes run. You will find in the list below all of the successful patterns described in the forums. I know there are thousands of fly patterns and just as many ways to fish them, not to mention numerous other flies that are effective in these waterways. This is simply a collection of what's been described in forum posts. I did my best to include each fly as it was described verbatim.
Four Mile Run
s 14-6 beadhead nymphs
s 8-6 sh*t flies (carp and others)
Chart popper and Dave's hopper (tilapia and others)
s 2-6 Clouser minnows (chart/white, olive/white, white, yellow)
s 10 black nose dace streamer
s 12-10 beadhead woolly buggers (black, white)
Foam hoppers
“medium and small” blue poppers
s 10 ghost shrimp
Adams
elk hair caddis
damselfly nymphs
Holmes Run
s 16 beadhead emergers
s 14 attractors
woolly buggers (black, chart, olive)
pearl zonkers
beadhead hare's ear nymph
pheasant tail nymph
“flashy beadhead nymph(s)”
San Juan worms
olive beadhead caddis nymph