Figure 2 Different actin regulators play distinct roles in actin dynamics in lymphocytes. As actin-monomer-binding proteins, profilin and thymosin beta 4 (Tβ4) bind G-actin and prevent it from polymerizing, while formins act in an opposite manner, promoting actin filament polymerization. The activation of Arp2/3 complex requires NPFs including WAVE, JMY, WASp/N-WASp, WASH, and WAHMM, which is needed for branching F-actin. The severing of F-actin is mediated by cofilin. In the above process, actin undergoes dynamic changes in lymphocytes, thereby regulating cellular activity and function.
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