Fat cells. derived stem cells further treatment of juvenile diabetes

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Diabetes education in Indian regional languagaes
a blog to develop Diabetes education topics in Indian regional
languages. concentrating on Hindi,telugu tamil to begin with but soon
to extend to other indian languages

Friday, August 29, 2008
Fat cells. derived stem cells further treatment of juvenile diabetes
About one year ago,

I received and e-mail from a father, asking about whether he should
have a son take this treatment, which is being offered by a doctor
from Gujarat.

that time. I had cautioned him to tread carefully and wait for and
year or two before jumping. The gun.

although I had checked up the credentials of Dr.H.L.Trivedi.

his current and chills were impeccable,

but the lack of animal experimentation, and also lack of any published
papers on this approach.

made me suspicious of the claims.

but I was waiting for a Publication in a peer reviewed Journal.

today while searching I came across the above article.

I am surprised that this has not caused a widespread sensation and the
news media.

I have ordered for the article, once I have read article I will post
my opinion.

I will also post a common man's explanation of what exactly was done,
and what were the results.

and what we can expect in future.

the abstract of the article given below.

http://www.ncbi.nlm.nih.gov/pubmed/18555133


: Transplant Proc. 2008 May;40(4):1135-9.
Links
Human adipose tissue-derived mesenchymal stem cells combined with
hematopoietic stem cell transplantation synthesize insulin.
Trivedi HL, Vanikar AV, Thakker U, Firoze A, Dave SD, Patel CN, Patel
JV, Bhargava AB, Shankar V.
Department of Nephrology and Transplantation Medicine, G. R. Doshi and
K. M. Mehta Institute of Kidney Diseases and Research Centre, Dr. H.L.
Trivedi Institute of Transplantation Sciences, Ahmedabad, Anand,
India. ikdr...@sancharnet.in
BACKGROUND: Type 1 diabetes mellitus (DM) is an autoimmune disorder
with disturbed glucose/insulin metabolism, which has no medical
treatment other than life-long insulin therapy, despite which 30% of
subjects develop organ failure. Herein we have reported the use of
human adipose-tissue-derived, insulin-making mesenchymal stem cells (h-
AD-MSC) transfused with unfractionated cultured bone marrow (CBM) in 5
insulinopenic DM patients. PATIENTS AND METHODS: Five (M:F, 2:3)
insulinopenic DM patients of 0.6 to 10 years' duration, ages 14 to 28
years under treatment insulin (Human with 14-70 U/d) showed
postprandial blood sugars between 156 to 470 mg%, glycosylated
hemoglobin 6.8% to 9.9% and c-peptide levels of 0.02 to 0.2 ng/mL.
They underwent intraportal administration of xenogeneic-free h-AD-MSC
(mean dose = 1.5 mL; cell counts, 2.1 x 10(3)/muL). The CD45-/90+/
73(+) cells (29.8/16.8%) showed c-peptide levels of 3.08 ng/mL,
insulin level of 1578 micro IU/mL. The aliquot was supplemented with
CBM (mean dose 94 mL with cell counts: 18.7 x 10(3)/microL) containing
CD45-/34+ elements of 0.93%. The Institutional Review Board approved
the study protocol and consent forms. RESULTS: All patients were
successfully infused CBM plus h-AD-MSC without any untoward effects
and showed 30% to 50% decreased insulin requirements with 4- to 26-
fold increased serum c-peptide levels, with a mean follow-up of 2.9
months. CONCLUSION: This report describes safe and effective treatment
of insulinopenic diabetics using insulin-producing h-AD-MSC plus CBM
without xenogeneic materials.
PMID: 18555133 [PubMed - indexed for MEDLINE]

some interesting articles on Dr. Trivedi realy fascinating.



http://goggly.blogspot.com/2006/02/real-life-hero-of-swades.html

{ the original email which alerted me to dr. Trivedis experiments .


prakash...@gmail.com
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external usenet poster

Posts: 1
DR H L TRIVEDI OF AHMEDABAD, GUJARAT, INDIA IS ON WAY TO CURE TYPE 1 /
JUVENILE DIABETES ?
DR H L TRIVEDI OF AHMEDABAD, GUJARAT, INDIA IS ON WAY TO CURE TYPE 1 /
JUVENILE DIABETES ?Here in India, ETV Gujarati telecasted interview of
Dr H L Trivedi on15th August 2007.Click the link to see the news in
detail:-http://www.medicaldaily.net/link.asp...Gujarat%20docsOn 17th,
I contact his hospital TELEPHONICALLY & inquired about theavailability
of the treatment to Diabetics; especially about my 16 yrJuvenile
Diabetic only Son*. A lady named Nalinibahen, replied on hisbehalf
over the telephone that I may go to there in Ahmedabad duringany
Monday to Friday with prior appoint. On inquiry, She gotconfirmation
that blood group of my son & of mine is equal. She toldme about the
procedure that on arrival, they, through minor surgery,collect a piece
of fat from my stomack & let us leave the hospital forabout 15 days.
During these period, they will cultivate stem cellsfrom it. When stem
cells r ready from the fat, they will call us fortreatment of my
Juvenile/Type 1 Diabetic Son. She informed me overTELEPHONE that they
will transplant the stem cell into lever of thepatient. After that,
the patient has to let admitted for about 1month. On inquiry, she told
me their charges, Rs. 1 Lac.WHAT DO U THINK ABOUT THIS NEWS WHEN SUCH
TYPE OF RESEARCES ARECONTINEOUSLY GOING ON ALL OVER GLOBE ?HONEST
OPINION PLEASE...!!!Prakash Thakrar, India}
Posted by Dr.Hariharan Ramamurthy at 8:48 AM