Journal club Sunday!

[Lindsay]

Sorry for the late notice.
Elad will present:
http://www.sciencemag.org/content/333/6047/1307.abstract

Engineered biological systems that integrate multi-input sensing,
sophisticated information processing, and precisely regulated
actuation in living cells could be useful in a variety of
applications. For example, anticancer therapies could be engineered to
detect and respond to complex cellular conditions in individual cells
with high specificity. Here, we show a scalable transcriptional/
posttranscriptional synthetic regulatory circuit—a cell-type
“classifier”—that senses expression levels of a customizable set of
endogenous microRNAs and triggers a cellular response only if the
expression levels match a predetermined profile of interest. We
demonstrate that a HeLa cancer cell classifier selectively identifies
HeLa cells and triggers apoptosis without affecting non-HeLa cell
types. This approach also provides a general platform for programmed
responses to other complex cell states.


Hope to see you there!
Lindsay

[Enas Abu Shah]

Hey Lindsay,

It was really a short notice :(

I wanted to come, it is an interesting subject, but I just saw it this morning since I was with a dead laptop all weekend!

next time I guess,

Enas