reminder: Sunday, July 17th at 12:00 in physics 377

[Lindsay]

Ori will present this paper: http://www.sciencemag.org/content/329/5993/856.full

Title: Rational Design of Envelope Identifies Broadly Neutralizing
Human Monoclonal Antibodies to HIV-1

Abstract: Cross-reactive neutralizing antibodies (NAbs) are found in
the sera of many HIV-1–infected individuals, but the virologic basis
of their neutralization remains poorly understood. We used knowledge
of HIV-1 envelope structure to develop antigenically resurfaced
glycoproteins specific for the structurally conserved site of initial
CD4 receptor binding. These probes were used to identify sera with
NAbs to the CD4-binding site (CD4bs) and to isolate individual B cells
from such an HIV-1–infected donor. By expressing immunoglobulin genes
from individual cells, we identified three monoclonal antibodies,
including a pair of somatic variants that neutralized over 90% of
circulating HIV-1 isolates. Exceptionally broad HIV-1 neutralization
can be achieved with individual antibodies targeted to the
functionally conserved CD4bs of glycoprotein 120, an important insight
for future HIV-1 vaccine design.

See you there!

Lindsay

[Enas Abu Shah]

Hi Lindsey,

I am writing to tell you that I might not make it to tomorrow's meeting, unless you want to move it to the afternoon something came up in the morning and I won't be in the Technion.

Sorry for the short notice.

Enas