Aphanizomenon flos-aquae (AFA)

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Swarfmaker

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Sep 17, 2010, 12:34:24 PM9/17/10
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Aphanizomenon flos-aquae (AFA)

Blue Green Algae health benefit
Blue green algae are not really algae, but they actually are more
closely related to bacteria. Because they are photosynthetic and
aquatic, cyanobacteria are often called "blue-green algae". This name
is convenient for talking about organisms in the water that make their
own food, but does not reflect any relationship between the
cyanobacteria and other organisms called algae. Cyanobacteria are
relatives of the bacteria, not eukaryotes. Cyanobacteria are aquatic
and photosynthetic, that is, they live in the water, and can
manufacture their own food. Because they are bacteria, they are quite
small and usually unicellular, though they often grow in colonies
large enough to see. They have the distinction of being the oldest
known fossils, more than 3.5 billion years old. Cyanobacteria are
still around; they are one of the largest and most important groups of
bacteria on earth.

The two types of Blue-Green Algae

Blue green algae are an important part of the food chain in lakes and
ponds worldwide. The two main blue-green types are Spirulina and
Aphanizomenon flos-aquae (AFA). AFA is harvested from Upper Klamath
Lake in Oregon and then freeze-dried and sold in capsules and other
forms...
http://www.raysahelian.com/bluegreenalgae.html

StemEnhance:
When you take two capsules, the ingredients help to support the
release of stem cells from the bone marrow into the bloodstream.
Through a natural process, those stem cells then travel to areas of
the body where they are most needed... Adult stem cells are most
abundantly found in bone marrow. Stem cells circulate and function to
replace dysfunctional cells, thus fulfilling the natural process of
maintaining optimal health. StemEnhance supports the release of adult
stem cells from bone marrow into circulation...
StemTech HealthSciences of Klamath Falls, Oregon
http://www.stemtechhealth.com/

Not everyone is so enthusiastic about the product:

StemTech HealthSciences... would like you to believe that StemEnhance™
can help many health problems. The product's label describes it as an
extract of Aphanizomenon flos aquae, a species of blue-green algae
harvested from a lake in Klamath Lake in Oregon. The retail price for
a bottle of 60 capsules is about $60. The recommended dosage is 2-4
capsules per day.
Before taking any product, it is advisable to know whether it has been
proven safe and effective for its intended purpose(s). With respect to
StemEnhance, the following questions would have to be answered:

What evidence shows that taking StemEnhance will improve anyone's
health?
Has any study shown that people improved their health as a result
of taking it?
What evidence shows that StemEnhance is safe for long-term use?
How can users be certain that long-term use will not cause
abnormal tissue growth?
For whom is the product advisable?
Who should not take it?
http://www.mlmwatch.org/04C/Stemtech/stemtech.html

Honestly, I don't know if StemEnhance or products like it would help
repair the damage caused by neurodegenerative diseases or not. I hope
they do. I hope we find something that helps. But I don't know. I
just thought that you would like to know that it exists so you can do
your own research and make up your own mind.

Since this is a supplement, is there someone else selling it? Is it
available in an "unrefined" state. For example, the supplement
curcumin is the extract of the cury spice turmeric. But, you would
have to eat 18 times as much turmeric. What I have been able to find
about this product is that the it is extracted from a blue-green algae
called Aphanizomenon flos-aquae (AFA). I checked some vitamin
distributors and found that you can get AFA from several of them. So
instead of buying this product, I am going to look into trying AFA. I
don't know how much or how often.

(WO/2008/000430) ALPHANIZOMENON [sic] FLOS AQUAE PREPARATION, EXTRACTS
AND PURIFIED COMPONENTS THEREOF FOR THE TREATMENT OF NEUROLOGICAL,
NEURODEGENERATIVE AND MOOD DISORDERS

WO 2008000430 20080103

APHANIZOMENON FLOS AQUAE PREPARATION, EXTRACTS AND PURIFIED COMPONENTS
THEREOF FOR THE TREATMENT OF NEUROLOGICAL, NEURODEGENERATIVE AND MOOD
DISORDERS

The present invention relates to the microalga Aphanizomenon Flos
Aquae Aquae Ralfs ex Born. & Flah. Var. flos aquae (AFA Klamath). More
precisely, the invention provides extracts of AFA Klamath and purified
components thereof useful for the prevention or treatment of
neurological, neurodegenerative and mood conditions or diseases...
Phenylethylamine (PEA) is an endogenous amine synthesized by
decarboxylation of phenylalanine in dopaminergic neurons of the
nigrostriatal system, and may act as a neuromodulator of catecholamine
neurotransmission in the brain... Moreover, once ingested PEA can
easily pass through the blood-brain barrier and stimulate the release
of dopamine from the nigrostriatal tissue even at low dosages...

Description of the invention

The invention is based on the identification, in the microalga
Aphanizomenon Flos Aquae Aquae Ralfs ex Born. & Flah. Var. flos aquae
(AFA Klamath), of substances that, alone or in combination, exert
beneficial effects on various neurological diseases, conditions,
dysfunctions or disorders, including neurodegenerative diseases such
as Alzheimer's and Parkinson's, multiple sclerosis, hyperactivity and
attention deficit disorders (ADHD), autism, depression, memory deficit
and mood disturbances. In particular, it has been found that AFA
Klamath microalga contains, besides phenylethylamine, which is a
neuromodulator characterized by dopaminergic and noradrenergic
activity, specific molecules which quite surprisingly proved to be
very effective inhibitors of the enzyme monoaminoxidase B (MAO-B),
namely: a) the specific AFA-phytochrome; b) the AFA-phycobiliprotein
complex containing a phycobilisome formed by C-phycocyanin (C-PC) and
phycoerythrocyanin (PEC, including its chromophore phycoviolobilin or
PVB) ("AFA-phycocyanins"); c) mycosporine-like amino acids or MAAs.
This finding is very important since the PEA contained in the algae,
unless protected by MAO-B inhibitors, would be rapidly destroyed upon
ingestion by the MAO-B enzyme...
http://www.wipo.int/pctdb/en/wo.jsp?WO=2008000430&IA=EP2007005622&DISPLAY=DESC

Marine Toxins :: analysis
http://lib.bioinfo.pl/meid:37072

Bioactive Compounds From Cyanobacteria and Microalgae: An Overview
Critical Reviews in Biotechnology
Posted on: Sunday, 23 October 2005, 03:01 CDT

By Singh, Sawraj; Kate, Bhushan N; Banerjee, U C

ABSTRACT Cyanobacteria (blue-green algae) are photosynthetic
prokaryotes used as food by humans. They have also been recognized as
an excellent source of vitamins and proteins and as such are found in
health food stores throughout the world. They are also reported to be
a source of fine chemicals, renewable fuel and bioactive compounds.
This potential is being realized as data from research in the areas of
the physiology and chemistry of these organisms are gathered and the
knowledge of cyanobacterial genetics and genetic engineering
increased. Their role as antiviral, anti- tumour, antibacterial, anti-
HIV and a food additive have been well established. The production of
cyanobacteria in artificial and natural environments has been fully
exploited. In this review the use of cyanobacteria and microalgae,
production processes and biosynthesis of pigments, colorants and
certain bioactive compounds are discussed in detail. The genetic
manipulation of cyanobacteria and microalgae to improve their quality
are also described at length.
http://www.redorbit.com/news/science/281044/bioactive_compounds_from_cyanobacteria_and_microalgae_an_overview/
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