Davunetide
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Swarfmaker
Dec 2, 2010, 7:52:32 AM12/2/10
to Alzheimer's Medicines Supplements and Treatments
Davunetide (AL-108) in Predicted Tauopathies - Pilot Study
This study is currently recruiting participants.
Verified by University of California, San Francisco, January 2010
Purpose
The primary objective of the study is to obtain preliminary safety and
tolerability data with davunetide (NAP, AL-108) in patients with a
tauopathy (frontotemporal lobar degeneration [FTLD] with predicted tau
pathology, corticobasal degeneration syndrome [CBS] or progressive
supranuclear palsy [PSP]). The secondary objectives of this study are
to obtain preliminary data on short term changes (at 12 weeks) in a
variety of clinical, functional and biomarker measurements from
baseline, including cerebrospinal fluid (CSF) tau levels, eye
movements, and brain MRI measurements.
http://clinicaltrials.gov/ct2/show/NCT01056965
Exclusion criterion #6 of the clinical trial announcement provides an
intriguing list of "putative [generally regarded as] disease-modifying
agent directed at tau": lithium, methylene blue, tramiprosate, ketone
bodies, Dimebon.
Lithium carbonate, citrate, and orotate are readily available.
Unfortunately, aside from it apparent effectiveness in treating
bipolar disorder and ALS, I have not heard much positive about its use
for treating tauopathies.
Methylene blue is an old drug that can still be obtained from some
specialty pharmacies.
Tramiprosate (a.k.a. homotaurine) is a new one to me. However, from
the brief summary I have read, its target is the amyloid beta of
Alzheimer's disease, not tau.
"Ketone bodies" are what the liver dumps into the blood stream when
"medium chain triglycerides" (MCTs) are in one's diet. Some MCTs are
caprylic, capric, and lauric (fatty) acids. Caprylic acid is the
active ingredient in the medical food Axona. Caprylic and capric acids
are the constituents of "MCT oils", and caprylic, capric and lauric
acids are abundant in common coconut oil. Again, I have never read
that MCT oils and the ketone bodies they generate would affect the tau
protein corruption problem.
Dimebon is a Russian antihistamine that is currently being
investigated for its positive effect on Alzheimer's disease symptoms.
This study is currently recruiting participants.
Verified by University of California, San Francisco, January 2010
Purpose
The primary objective of the study is to obtain preliminary safety and
tolerability data with davunetide (NAP, AL-108) in patients with a
tauopathy (frontotemporal lobar degeneration [FTLD] with predicted tau
pathology, corticobasal degeneration syndrome [CBS] or progressive
supranuclear palsy [PSP]). The secondary objectives of this study are
to obtain preliminary data on short term changes (at 12 weeks) in a
variety of clinical, functional and biomarker measurements from
baseline, including cerebrospinal fluid (CSF) tau levels, eye
movements, and brain MRI measurements.
http://clinicaltrials.gov/ct2/show/NCT01056965
Exclusion criterion #6 of the clinical trial announcement provides an
intriguing list of "putative [generally regarded as] disease-modifying
agent directed at tau": lithium, methylene blue, tramiprosate, ketone
bodies, Dimebon.
Lithium carbonate, citrate, and orotate are readily available.
Unfortunately, aside from it apparent effectiveness in treating
bipolar disorder and ALS, I have not heard much positive about its use
for treating tauopathies.
Methylene blue is an old drug that can still be obtained from some
specialty pharmacies.
Tramiprosate (a.k.a. homotaurine) is a new one to me. However, from
the brief summary I have read, its target is the amyloid beta of
Alzheimer's disease, not tau.
"Ketone bodies" are what the liver dumps into the blood stream when
"medium chain triglycerides" (MCTs) are in one's diet. Some MCTs are
caprylic, capric, and lauric (fatty) acids. Caprylic acid is the
active ingredient in the medical food Axona. Caprylic and capric acids
are the constituents of "MCT oils", and caprylic, capric and lauric
acids are abundant in common coconut oil. Again, I have never read
that MCT oils and the ketone bodies they generate would affect the tau
protein corruption problem.
Dimebon is a Russian antihistamine that is currently being
investigated for its positive effect on Alzheimer's disease symptoms.
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